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Synfacts 2018; 14(01): 0037
DOI: 10.1055/s-0036-1591077
DOI: 10.1055/s-0036-1591077
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Gold(I)-Catalyzed Stereoselective Synthesis of Deoxyglycosides
Further Information
Publication History
Publication Date:
15 December 2017 (online)

Significance
Deoxyhexose structures can be found in a wide range of natural products. The authors have developed an α-stereoselective catalytic synthesis of deoxyglycosides from glycals by using Au(I)/AgOTf.
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Comment
The reaction can be applied to a broad range of glycals and alcohols to give α-deoxyglycosides in high yields and with excellent selectivity. The utility of the reaction was demonstrated by the synthesis of oligosaccharides through the coupling reaction followed by deprotection.
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