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Synlett 2018; 29(01): 79-84
DOI: 10.1055/s-0036-1591210
DOI: 10.1055/s-0036-1591210
letter
Copper(I) Iodide-Catalyzed (Het)arylation of Diethyl Malonate with (Het)aryl Bromides by Using 1,3-Benzoxazole as a Ligand
The research has been supported by National Natural Science Foundation of China (Grant No.U1463201, 21522604 and 21402240) and Jiangsu Province Natural Science Fund (Grant No.BK20150031)Further Information
Publication History
Received: 20 June 2017
Accepted after revision: 26 July 2017
Publication Date:
26 October 2017 (online)
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Abstract
An efficient Ullmann-type coupling of aryl bromides with diethyl malonate in the presence of copper(I) iodide and 1,3-benzoxazole is presented. This method has a broad substrate scope (heterocyclic and phenyl bromides) and good functional-group tolerance (OMe, Me, Ac, CN, NO2, F, and Cl). Moreover, less time is needed to reach full conversion (3–9 hours).
Key words
Ullmann coupling - benzoxazole - copper catalysis - aryl bromides - hetarylation - arylationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591210.
- Supporting Information