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Synfacts 2017; 13(11): 1199
DOI: 10.1055/s-0036-1591365
DOI: 10.1055/s-0036-1591365
Organo- and Biocatalysis
Cyclobutadienes via an Organocascade
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. Oktober 2017 (online)
![](https://www.thieme-connect.de/media/synfacts/201711/i_b086_s1_10-1055_s-0036-1591365.gif)
Significance
The Wang group reports an organocatalytic [2+2] cycloaddition between α,β-unsaturated aldehydes and ynals. This reaction is catalyzed by secondary amines and generates cyclo-butadienes in high yields under mild conditions.
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Comment
The authors suggest that the reaction follows a dienamine–iminium–allenamine cascade sequence furnishing cyclobutadienes as products. Typically high temperatures are required for the synthesis of cyclobutadienes. This method requires only room temperature, hence overcoming a limitation of previous methods.
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![](https://www.thieme-connect.de/media/synfacts/201711/i_b086_s1_10-1055_s-0036-1591365.gif)