Keeping the Zika Virus Out of the Assisted Reproductive Technology Laboratory

Abstract

The Zika virus (ZIKV) epidemic spreading through South and Central America, as well as several U.S. territories has created worldwide concern as the linkage between ZIKV infection and microcephaly has been established. Both travel associated and sexually transmitted cases have put couples who live in nonendemic areas at risk of falling victim to effects of Zika. The presence of ZIKV within reproductive tissues may pose a significant threat to patients seeking fertility services and to safety of the tissues currently housed in assisted reproductive technology (ART) laboratories. There are still many unanswered questions regarding the mechanism of ZIKV sexual transmission. Just as strict guidelines have been set regarding the screening and handling of human immunodeficiency virus, hepatitis C virus, and hepatitis B virus–positive patient tissues, similar recommendations are needed to prevent contamination and inadvertent transmission within the ART laboratory.

Keywords

Zika virus - assisted reproductive technology - sexual transmission - laboratory

• References

• 1 Foy BD, Kobylinski KC, Chilson Foy JL , et al. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis 2011; 17 (5) 880-882
• 2 Berry WR, Gottesfeld RL, Alter HJ, Vierling JM. Transmission of hepatitis B virus by artificial insemination. JAMA 1987; 257 (8) 1079-1081
• 3 Araneta MR, Mascola L, Eller A , et al. HIV transmission through donor artificial insemination. JAMA 1995; 273 (11) 854-858
• 4 Bielanski A, Bergeron H, Lau PC, Devenish J. Microbial contamination of embryos and semen during long term banking in liquid nitrogen. Cryobiology 2003; 46 (2) 146-152
• 5 Bingham AM, Cone M, Mock V , et al. Comparison of test results for Zika virus RNA in urine, serum, and saliva specimens from persons with travel-associated Zika virus disease – Florida, 2016. MMWR Morb Mortal Wkly Rep 2016; 65 (18) 475-478
• 6 Mlakar J, Korva M, Tul N , et al. Zika virus associated microcephaly. N Engl J Med 2016; 374 (10) 951-958
• 7 Quicke KM, Bowen JR, Johnson EL , et al. Zika virus infects human placental macrophages. Cell Host Microbe 2016; 20 (1) 83-90
• 8 Miner JJ, Cao B, Govero J , et al. Zika virus infection during pregnancy in mice causes placental damage and fetal demise. Cell 2016; 165 (5) 1081-1091
• 9 Centers for Disease Control and Prevention. Zika virus disease in the United States, 2015–2016. Available at: http://www.cdc.gov/zika/geo/united-states.html . Accessed June 19, 2016
• 10 Food and Drug Administration. Donor Screening Recommendations to Reduce the Risk of Transmission of Zika Virus by Human Cells, Tissues, and Cellular and Tissue-Based Products. Rockville, MD: Center for Biologics and Research; 2016
• 11 Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential sexual transmission of Zika virus. Emerg Infect Dis 2015; 21 (2) 359-361
• 12 Atkinson B, Hearn P, Afrough B , et al. Detection of Zika virus in semen. Emerg Infect Dis 2016; 22 (5) 940
• 13 Rowland A, Washington CI, Sheffield JS, Pardo-Villamizar CA, Segars JH. Zika virus infection in semen: a call to action and research. J Assist Reprod Genet 2016; 33 (4) 435-437
• 14 Tang H, Hammack C, Ogden SC , et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell 2016; 18 (5) 587-590
• 15 Driggers RW, Ho CY, Korhonen EM , et al. Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. N Engl J Med 2016; 374 (22) 2142-2151
• 16 Noronha Ld, Zanluca C, Azevedo ML, Luz KG, Santos CN. Zika virus damages the human placental barrier and presents marked fetal neurotropism. Mem Inst Oswaldo Cruz 2016; 111 (5) 287-293
• 17 Adibi JJ, Marques Jr ET, Cartus A, Beigi RH. Teratogenic effects of the Zika virus and the role of the placenta. Lancet 2016; 387 (10027) 1587-1590
• 18 Martines RB, Bhatnagar J, Keating MK , et al. Notes from the field: evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses – Brazil, 2015. MMWR Morb Mortal Wkly Rep 2016; 65 (6) 159-160
• 19 Gimenes F, Souza RP, Bento JC , et al. Male infertility: a public health issue caused by sexually transmitted pathogens. Nat Rev Urol 2014; 11 (12) 672-687
• 20 Ma M, Zhu Y, Wang D , et al. Research on the vertical transmission of hepatitis C gene from father-to-child via human sperm. Clin Lab 2016; 62 (1–2) 1-6
• 21 Foresta C, Patassini C, Bertoldo A , et al. Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa. PLoS ONE 2011; 6 (3) e15036
• 22 Tebourbi L, Testart J, Cerutti I, Moussu JP, Loeuillet A, Courtot AM. Failure to infect embryos after virus injection in mouse zygotes. Hum Reprod 2002; 17 (3) 760-764
• 23 Gornet M, Bracero NJ, Segars JH. Zika virus in semen: what we know and what we need to know. Semin Reprod Med 2006;
• 24 Neighbour PA. Studies on the susceptibility of the mouse preimplantation embryo to infection with cytomegalovirus. J Reprod Fertil 1978; 54 (1) 15-20
• 25 Vanroose G, Nauwynck H, Van Soom A, Vanopdenbosch E, de Kruif A. Susceptibility of zona-intact and zona-free in vitro-produced bovine embryos at different stages of development to infection with bovine herpesvirus-1. Theriogenology 1997; 47 (7) 1389-1402
• 26 Chan PJ, Su BC, Tredway DR, Seraj M, Seraj IM, King A. Uptake of exogenous human papilloma virus L1 DNA by oocytes and detection by the polymerase chain reaction. J Assist Reprod Genet 1992; 9 (6) 531-533
• 27 Chan PJ, Seraj IM, Kalugdan TH, King A. Blastocysts exhibit preferential uptake of DNA fragments from the E6-E7 conserved region of the human papillomavirus. Gynecol Oncol 1995; 58 (2) 194-197
• 28 Devaux A, Soula V, Sifer C , et al. Hepatitis C virus detection in follicular fluid and culture media from HCV+ women, and viral risk during IVF procedures. Hum Reprod 2003; 18 (11) 2342-2349
• 29 Cobo A, Bellver J, de los Santos MJ, Remohí J. Viral screening of spent culture media and liquid nitrogen samples of oocytes and embryos from hepatitis B, hepatitis C, and human immunodeficiency virus chronically infected women undergoing in vitro fertilization cycles. Fertil Steril 2012; 97 (1) 74-78
• 30 Dupont-Rouzeyrol M, Biron A, O'Connor O, Huguon E, Descloux E. Infectious Zika viral particles in breastmilk. Lancet 2016; 387 (10023) 1051
• 31 Petersen EE, Polen KN, Meaney-Delman D , et al. Update: interim guidance for health care providers caring for women of reproductive age with possible Zika virus exposure – United States, 2016. MMWR Morb Mortal Wkly Rep 2016; 65: 315-322
• 32 Tedder RS, Zuckerman MA, Goldstone AH , et al. Hepatitis B transmission from contaminated cryopreservation tank. Lancet 1995; 346 (8968) 137-140
• 33 Wong KM, Mastenbroek S, Repping S. Cryopreservation of human embryos and its contribution to in vitro fertilization success rates. Fertil Steril 2014; 102 (1) 19-26
• 34 Bielanski A, Nadin-Davis S, Sapp T, Lutze-Wallace C. Viral contamination of embryos cryopreserved in liquid nitrogen. Cryobiology 2000; 40 (2) 110-116
• 35 Practice Committee of American Society for Reproductive Medicine; Practice Committee of Society for Assisted Reproductive Technology. Revised guidelines for human embryology and andrology laboratories. Fertil Steril 2008; 90 (5, Suppl): S45-S59
• 36 The Association of American Blood Banks. Zika, Dengue, and Chikungunya Viruses. Bethesda, MD: Association Bulletin #16–04; 2016. Available at: https://www.aabb.org/programs/publications/bulletins/Documents/ab16-04.pdf . Accessed September 1, 2016
• 37 Palermo GD, Neri QV, Takeuchi T, Rosenwaks Z. ICSI: where we have been and where we are going. Semin Reprod Med 2009; 27 (2) 191-201