The Role of Bacterial Natural Products in Predator Defense

Martin Klapper; Johannes Arp; Markus Günther; Pierre Stallforth

doi:10.1055/s-0037-1609226

Synlett, Table of Contents

Synlett 2018; 29(05): 537-541
DOI: 10.1055/s-0037-1609226

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The Role of Bacterial Natural Products in Predator Defense

Martin Klapper

Junior Research Group Chemistry of Microbial Communication, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany Email: pierre.stallforth@leibniz-hki.de

,

Johannes Arp

Junior Research Group Chemistry of Microbial Communication, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany Email: pierre.stallforth@leibniz-hki.de

,

Markus Günther

Junior Research Group Chemistry of Microbial Communication, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany Email: pierre.stallforth@leibniz-hki.de

,

Pierre Stallforth *

Junior Research Group Chemistry of Microbial Communication, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany Email: pierre.stallforth@leibniz-hki.de

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Abstract

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Abstract

Bacterially produced natural products, i.e., low molecular weight metabolites, or derivatives thereof, constitute most of the commercially available antibiotics as well as a large proportion of anticancer drugs. While indispensable as therapeutically active compounds, the ecological roles of many of these bacterial natural products remain poorly understood. Here, we discuss these metabolites in light of microbial predator defense: soil bacteria are constantly threatened by a variety of predators and the secretion of low molecular weight toxins enables the producing bacteria to kill or deter the predator. Conversely, a deeper understanding of these microbial predator–prey interactions can lead to the discovery of novel compounds, which in turn can be of therapeutic use.

Key words

natural products - biosynthesis - secondary metabolites - pyreudiones - amoebae

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References

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