Total Synthesis of Astellatol: A Three-Decade Synthetic Puzzle

Nan Zhao; Shengling Xie; Hengjun Huang; Jing Xu

doi:10.1055/s-0037-1610149

Synlett, Table of Contents

Synlett 2018; 29(15): 1933-1936
DOI: 10.1055/s-0037-1610149

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Total Synthesis of Astellatol: A Three-Decade Synthetic Puzzle

Nan Zhao

Department of Chemistry, and Shenzhen Grubbs Institute, Southern University of Science and Technology, No. 1088 Xueyuan Ave. Nanshan, Shenzhen, Guangdong, 518055, P. R. of China Email: xuj@sustc.edu.cn

,

Shengling Xie

Department of Chemistry, and Shenzhen Grubbs Institute, Southern University of Science and Technology, No. 1088 Xueyuan Ave. Nanshan, Shenzhen, Guangdong, 518055, P. R. of China Email: xuj@sustc.edu.cn

,

Hengjun Huang

Department of Chemistry, and Shenzhen Grubbs Institute, Southern University of Science and Technology, No. 1088 Xueyuan Ave. Nanshan, Shenzhen, Guangdong, 518055, P. R. of China Email: xuj@sustc.edu.cn

,

Jing Xu *

Department of Chemistry, and Shenzhen Grubbs Institute, Southern University of Science and Technology, No. 1088 Xueyuan Ave. Nanshan, Shenzhen, Guangdong, 518055, P. R. of China Email: xuj@sustc.edu.cn

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Abstract

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Abstract

Here we briefly discuss and review our journey to achieve the first, enantiospecific total synthesis of a rare, complex sesterterpenoid, astellatol.

1 Introduction

2 Model Study of Reductive Radical Cyclization

3 Total Synthesis of Astellatol

4 Conclusion

Key words

sesterterpenoid - total synthesis - radical cyclization - Pauson–Khand reaction - trans-hydrindane

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References

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