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DOI: 10.1055/s-0037-1610166
Synthesis of β-Phenethyl Ethers by Base-Catalyzed Alcohol Addition Reactions to Aryl Alkenes
We thank Colorado State University for the startup funding used to support this work.Publication History
Received: 17 April 2018
Accepted after revision: 07 May 2018
Publication Date:
25 June 2018 (online)
![](https://www.thieme-connect.de/media/synlett/201817/lookinside/thumbnails/st-2018-p0243-sp_10-1055_s-0037-1610166-1.jpg)
Abstract
The direct anti-Markovnikov addition of alcohols to styrene derivatives represents a streamlined route to β-phenethyl ethers, a substructure frequently found in pharmaceuticals and other bioactive molecules. Here, we discuss how the development of such a reaction can complement and address limitations of current methods for β-phenethyl ether synthesis. In particular, we highlight our recent approach toward achieving this challenging alcohol addition reaction through P4-t-Bu superbase catalysis. A summary of compatible aryl alkenes and alcohols is provided to inform readers of potential applications of this new catalytic transformation, as well as its current limitations and future directions.
1 Introduction
2 Anti-Markovnikov Alcohol Addition to Aryl Alkenes: Background
3 Superbase-Catalyzed Alcohol Addition to Aryl Alkenes
4 Summary and Outlook
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