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Synfacts 2019; 15(03): 0283
DOI: 10.1055/s-0037-1611209
DOI: 10.1055/s-0037-1611209
Polymer-Supported Synthesis
Formal Hydroacylation of Alkynes on Mg3Al–CO3-Layered Double Hydroxide
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
15. Februar 2019 (online)
Key words
transition-metal-free reaction - layered double hydroxide - hydroacylation - alkynes - aldehydes![](https://www.thieme-connect.de/media/synfacts/201903/i_y010_s1_10-1055_s-0037-1611209.gif)
Significance
Mg3Al–CO3-layered double hydroxide (Mg3Al–CO3 LDH) catalyzed the formal hydroacylation of terminal arylalkynes with aromatic aldehydes under argon to give the corresponding diaryl α,β-unsaturated ketones in up to 85% yield (24 examples).
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Comment
In the reaction of phenylacetylene with p-anisaldehyde, Mg3Al–CO3 LDH was recovered and reused three times with a slight loss of its catalytic activity (fresh: 91% yield; third reuse: 73% yield).
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![](https://www.thieme-connect.de/media/synfacts/201903/i_y010_s1_10-1055_s-0037-1611209.gif)