Li X,
Zhou B,
Yang R.-Z,
Yang F.-M,
Liang R.-X,
Liu R.-R,
Jia YX.
* Zhejiang University of Technology, Hangzhou, P. R. of China
Palladium-Catalyzed Enantioselective Intramolecular Dearomative Heck Reaction.
J. Am. Chem. Soc. 2018;
140: 13945-13951
Key words
palladium catalysis - dearomatization - Heck reaction
Significance
The authors report an enantioselective palladium-catalyzed dearomative Heck process, which affords a variety of spiroheterocycles and benzo-fused heterocycles in high yields and enantioselectivities.
Comment
Various sets of conditions were developed, depending on the heterocyclic scaffold employed. A remarkable number of examples (88) were demonstrated, and the synthetic utility of the products was displayed by a series of derivatizations.
