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Synfacts 2019; 15(01): 0045
DOI: 10.1055/s-0037-1611386
Metals in Synthesis
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Palladium-Catalyzed Dearomative Heck Reaction

Contributor(s):
Mark Lautens
,
José F. Rodríguez
Li X, Zhou B, Yang R.-Z, Yang F.-M, Liang R.-X, Liu R.-R, Jia YX. * Zhejiang University of Technology, Hangzhou, P. R. of China
Palladium-Catalyzed Enantioselective Intramolecular Dearomative Heck Reaction.

J. Am. Chem. Soc. 2018;
140: 13945-13951
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Further Information

Publication History

Publication Date:
14 December 2018 (online)

 
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Key words

palladium catalysis - dearomatization - Heck reaction

Significance

The authors report an enantioselective palladium-catalyzed dearomative Heck process, which affords a variety of spiroheterocycles and benzo-fused heterocycles in high yields and enantioselectivities.


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Comment

Various sets of conditions were developed, depending on the heterocyclic scaffold employed. A remarkable number of examples (88) were demonstrated, and the synthetic utility of the products was displayed by a series of derivatizations.


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