Trichloroisocyanuric Acid Mediated High-Yielding Synthesis of N-Acylbenzotriazoles under Mild Reaction Conditions

Mala Singh; Anoop S. Singh; Nidhi Mishra; Anand K. Agrahari; Vinod K. Tiwari

doi:10.1055/s-0037-1611724

Synthesis, Table of Contents

Synthesis 2019; 51(10): 2183-2190
DOI: 10.1055/s-0037-1611724

paper

Trichloroisocyanuric Acid Mediated High-Yielding Synthesis of N-Acylbenzotriazoles under Mild Reaction Conditions

Mala Singh

,

Anoop S. Singh

,

Nidhi Mishra

,

Anand K. Agrahari

,

Vinod K. Tiwari *

Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India Email: tiwari_chem@yahoo.co.in Email: Vinod.Tiwari@bhu.ac.in

› Author Affiliations

Abstract

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This manuscript is dedicated to the (Late) Prof. Alan R. Katritzky for his contributions to benzotriazole chemistry.

Abstract

N-Acylbenzotriazoles are achieved in good yields from the corresponding carboxylic acids by using only 0.35 equivalent of trichloroisocyanuric acid and 1.2 equivalents of PPh₃. The salient features of the developed reaction path include an economic, facile, base-free, and equally useful method in milligram to gram scale.

Key words

N-acylbenzotriazole - coupling reaction - trichloroisocyanuric acid

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References

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