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Thromb Haemost 1998; 80(03): 370-371
DOI: 10.1055/s-0037-1615213
Rapid Communications
Schattauer GmbH

Treatment with a GPIIb/IIIa Antagonist Inhibits Thrombin Generation in Platelet Rich Plasma from Patients

I. M. L. W. Keularts
1   From the Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
,
S. Béguin
1   From the Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
,
C. de Zwaan
1   Department of Cardiology, Academic Hospital, Maastricht, Maastricht, The Netherlands
,
H. C. Hemker
1   From the Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 17 March 1998

Accepted after revision 12 May 1998

Publication Date:
08 December 2017 (online)

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Summary

Infusion of the GPIIb/IIIa-inhibitor MK383 inhibits thrombin generation in platelet rich plasma by interfering with the production of platelet procoagulant phospholipid exposure. The effect is similar to that of 0.2 U/ml of heparin. Heparin infusion, well known to inhibit thrombin generation by fostering antithrombin activity, inhibits the formation of platelet-derived procoagulant microparticles, probably by decreasing the formation of free thrombin, which, under our circumstances, is the main platelet activator.

 

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