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Thromb Haemost 2001; 85(05): 787-792
DOI: 10.1055/s-0037-1615719
Review Article
Schattauer GmbH

Coagulation Factor VII in Middle-aged Women with and without Coronary Heart Disease

Margita Eriksson-Berg
1   Cardiology Unit and the Atherosclerosis Research Unit
,
Angela Silveira
2   Atherosclerosis Research Unit, King Gustaf V Research Institute Department of Medicine, Karolinska Hospital
,
Kristina Orth-Gomér
3   Department of Public Health Sciences, Division of Preventive Medicine, Karolinska Institutet, Stockholm, Sweden
,
Anders Hamsten
2   Atherosclerosis Research Unit, King Gustaf V Research Institute Department of Medicine, Karolinska Hospital
,
Karin Schenck-Gustafsson
1   Cardiology Unit and the Atherosclerosis Research Unit
› Author Affiliations
Further Information

Publication History

Received 09 May 2000

Accepted after resubmission 04 January 2000

Publication Date:
11 December 2017 (online)

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Summary

Epidemiological studies of coagulation factor VII as a risk factor for coronary heart disease (CHD), mainly conducted in men, have shown discrepant results. We examined the associations of coagulation factor VII antigen (VIIag) and activated factor VII (VIIa) with manifest CHD in a community-based case-control study of women aged ≤65 years. Mean plasma concentrations of VIIag and VIIa in patients and controls were 443 ± 108 and 418 ± 89 ng/L (p <0.01) and 5.26 ± 2.21 and 4.90 ± 1.65 ng/L (NS), respectively. The odds ratio (OR) for CHD for the highest versus the lowest quartile of VIIag was 1.75 (95% CI, 1.05 to 2.92). The adjusted OR was 0.76 (95% CI, 0.28-1.98) after controlling for other cardiovascular risk factors. The corresponding ORs for VIIa were non-significant. In conclusion, the plasma concentration of VIIa was not significantly increased in a large group of women with precocious CHD, and VIIag levels, although elevated, were not independently associated with manifest disease.

Keywords

Factor VII - lipoproteins - risk factors - myocardial infarction - coronary heart disease
 

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