Neuroendokrinologie der Alkoholabhängigkeit

F. Kiefer; K. Wiedemann

doi:10.1055/s-0038-1624365

Nervenheilkunde, Table of Contents

Nervenheilkunde 2003; 22(01): 19-23
DOI: 10.1055/s-0038-1624365

Original- und Übersichtsarbeiten/Original and Review Articles

Schattauer GmbH

Neuroendokrinologie der Alkoholabhängigkeit

Einfluss auf Affekt, Alkoholappetenz und CravingNeuroendocrinology of alcoholismeffects upon emotions and craving

Authors

F. Kiefer

¹Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Hamburg-Eppendorf
K. Wiedemann

¹Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Hamburg-Eppendorf

Abstract

Zusammenfassung

Insbesondere zwei psychiatrisch relevante Krankheitsbilder, die affektiven Störungen und die Störungen der Appetitregulation, werden aktuell durch Impulse aus der neuroendokrinologischen Forschung neuen biologischen Erklärungsmodellen zugänglich. Eine besondere Bedeutung kommt hierbei den Peptiden der HypothalamusHypophysen-Nebennierenrinden-Achse (HHN-Achse) zu, neuerdings aber auch weiteren modulierenden Neuropeptiden wie z.B. dem Leptin, dem atrialen natriuretischen Peptid (ANP) und dem β-Endorphin. Obwohl seit langer Zeit bekannt ist, dass sowohl Störungen der Stresshormon-Achse (HHN) als auch Störungen der Affektivität und der Appetitregulation bei Alkoholabhängigen ausgeprägt vorhanden sind, war der Einfluss von Neuropeptiden auf psychopathologische Veränderungen bei Alkoholabhängigkeit nur selten Gegenstand spezifischer Studien. Die vorliegende Übersicht fasst aktuelle Studien über die Wechselwirkungen zwischen Endokrinum und affektiven Syndromen sowie Suchtdruck bei der Alkoholabhängigkeit zusammen.

Summary

Impact of neuroendocrinologic research has been demonstrated especially regarding the regulation of affect and appetite. One well known central mechanism of action is the hypothalamic-pituitary-adrenocortical (HPA) axis, but moreover, some modulating peptides like leptin, atrial natriuretic peptide (ANP) and β-endorphin have been shown to reveal new insights and perspectives in the regulation of this system. Whereas disturbances of the HPA axis as well as disturbances in the regulation of affect and appetite occur regularly in alcohol addicts, interactions of neuropeptides and psychopathology in alcoholism have been studied rather seldom. This article summarizes some recent results on this topic.

Schlüsselwörter

Alkoholabhängigkeit - Endokrinologie - Affekt - Craving - Leptin - ANP - β-Endorphin

Keywords

Alcoholism - endocrinology - affective - craving - leptin - ANP - β-endorphin

Full Text

References

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