Effects of Thrombin on Factor VIII Activity: Stabilization of Factor VIII by Glycine Ethyl Ester

C. T Kisker

doi:10.1055/s-0038-1654161

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1967; 17(03/04): 381-387
DOI: 10.1055/s-0038-1654161

Originalarbeiten - Original Articles - Travaux Originaux

Schattauer GmbH

Effects of Thrombin on Factor VIII Activity: Stabilization of Factor VIII by Glycine Ethyl Ester

C. T Kisker^*

¹U. S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, Division of Biologies Standards, Bethesda, Maryland

› Author Affiliations

Abstract

Summary

The action of purified thrombin on a preparation of antihemophilic factor with fibrinogen has been studied. In the absence of active thrombin (thrombin inactivated with DFP) polymerization of fibrin by calcium was accompanied by significant losses of AHF. In the presence of thrombin and calcium, 0.3 M glycine ethyl ester resulted in a significant reduction in the loss of AHF activity.

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References

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