Kennedy CR,
Zhong H,
Macaulay RL,
Chirik PJ.
* Princeton University, USA
Regio- and Diastereoselective Iron-Catalyzed [4+4]-Cycloaddition of 1,3-Dienes.
J. Am. Chem. Soc. 2019;
141: 8557-8573
Key words
cycloaddition - diastereoselectivity - iron catalysis
Significance
Chirik and co-workers report a regio- and diastereoselective iron-catalyzed [4+4] cycloaddition of 1,3-dienes, leading to various substituted cyclooctadienes in excellent yields.
Comment
Remarkably, with the choice of the iron catalyst, the cyclodimerization can be controlled in a diastereoselective fashion. Extensive mechanistic studies were performed and catalytically relevant iron complexes were isolated and characterized.
