Mu Y,
Nguyen TT,
Koh MJ,
Schrock RR,
Hoveyda AH.
* Boston College, Chestnut Hill and Massachusetts Institute of Technology, Cambridge, USA
E- and
Z-, Di- and Tri-substituted Alkenyl Nitriles through Catalytic Cross-Metathesis.
Nat. Chem. 2019;
11: 478-487
Key words
alkenyl nitriles - cross-metathesis - molybdenum catalysis
Significance
Hoveyda and co-workers disclose the preparation of E- and Z-multiply-substituted alkenyl nitriles in high yields and excellent diastereoselectivities through molybdenum-catalyzed cross-metathesis reactions.
Comment
The choice of the molybdenum catalysis discussed in detail and the application of the methodology is demonstrated by the preparation of a wide range of biologically active substrates.
