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Synfacts 2019; 15(08): 0950
DOI: 10.1055/s-0039-1690479
DOI: 10.1055/s-0039-1690479
Peptide Chemistry
Azotide Ligands for Hetero-Diels–Alder Reactions
Further Information
Publication History
Publication Date:
18 July 2019 (online)
![](https://www.thieme-connect.de/media/synfacts/201908/i_h059_s1_10-1055_s-0039-1690479.gif)
Significance
Azotides, which are abundantly found as scaffolds in natural products, are known to coordinate metal ions. The author report new azotide ligands for enantioselective Lewis acid catalysis.
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Comment
The ligands were readily prepared from the chiral pool of amino acids and demonstrated enantioselectivity when used as ligands in a cobalt(II)-catalyzed hetero-Diels–Alder reaction.
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![](https://www.thieme-connect.de/media/synfacts/201908/i_h059_s1_10-1055_s-0039-1690479.gif)