Jacobsen CB,
Nielsen DS,
Meldal M.
*
Diness F.
* University of Copenhagen, Denmark
Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis.
J. Org. Chem. 2019;
84: 6940-6945
Key words
azotides - hetero-Diels–Alder reaction - cobalt catalysis
Significance
Azotides, which are abundantly found as scaffolds in natural products, are known to coordinate metal ions. The author report new azotide ligands for enantioselective Lewis acid catalysis.
Comment
The ligands were readily prepared from the chiral pool of amino acids and demonstrated enantioselectivity when used as ligands in a cobalt(II)-catalyzed hetero-Diels–Alder reaction.
