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Synfacts 2019; 15(08): 0945
DOI: 10.1055/s-0039-1690482
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Organcatalytic Transamination for the Synthesis of α-Amino Acids

Contributor(s):
Hisashi Yamamoto
,
Wataru Muramatsu
Kang Q.-K, Selvakumar S, Maruoka K. * Kyoto University, Japan and Guangdong University of Technology, Guangzhou, P. R. of China
Asymmetric Synthesis of α-Amino Acids by Organocatalytic Biomimetic Transamination.

Org. Lett. 2019;
21: 2294-2297
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Further Information

Publication History

Publication Date:
18 July 2019 (online)

 
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Key words

organocatalysis - transamination - keto esters - amino acids

Significance

Asymmetric metal-free transformation is one of the most useful and environmentally friendly techniques for the synthesis of chiral organic compounds. The authors describe a powerful method for the synthesis of α-amino acid derivatives catalyzed by novel chiral phase-transfer catalysts.


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Comment

This organocatalytic enantioselective transformation of α-keto esters with benzyl amines smoothly provides the corresponding α-amino acid derivatives in moderate yields with good enantioselectivities.


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