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Synfacts 2019; 15(08): 0945
DOI: 10.1055/s-0039-1690482
DOI: 10.1055/s-0039-1690482
Peptide Chemistry
Organcatalytic Transamination for the Synthesis of α-Amino Acids
Further Information
Publication History
Publication Date:
18 July 2019 (online)
![](https://www.thieme-connect.de/media/synfacts/201908/i_h063_s1_10-1055_s-0039-1690482.gif)
Significance
Asymmetric metal-free transformation is one of the most useful and environmentally friendly techniques for the synthesis of chiral organic compounds. The authors describe a powerful method for the synthesis of α-amino acid derivatives catalyzed by novel chiral phase-transfer catalysts.
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Comment
This organocatalytic enantioselective transformation of α-keto esters with benzyl amines smoothly provides the corresponding α-amino acid derivatives in moderate yields with good enantioselectivities.
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![](https://www.thieme-connect.de/media/synfacts/201908/i_h063_s1_10-1055_s-0039-1690482.gif)