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Synfacts 2019; 15(08): 0945
DOI: 10.1055/s-0039-1690482
DOI: 10.1055/s-0039-1690482
Peptide Chemistry
Organcatalytic Transamination for the Synthesis of α-Amino Acids
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. Juli 2019 (online)
Significance
Asymmetric metal-free transformation is one of the most useful and environmentally friendly techniques for the synthesis of chiral organic compounds. The authors describe a powerful method for the synthesis of α-amino acid derivatives catalyzed by novel chiral phase-transfer catalysts.
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Comment
This organocatalytic enantioselective transformation of α-keto esters with benzyl amines smoothly provides the corresponding α-amino acid derivatives in moderate yields with good enantioselectivities.
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