Kulinkovich OG.
*
Sviridov SV,
Vasilevski DA.
Belarusian State University, Minsk, Belarus
Titanium(IV) Isopropoxide-Catalyzed Formation of 1-Substituted Cyclopropanols in the Reaction of Ethylmagnesium Bromide with Methyl Alkanecarboxylates.
Synthesis 1991; 234-234
Key words
cyclopropanes - Grignard reagent - titanium
Significance
In 1991, Kulinkovich and co-workers reported the titanium-catalyzed reaction of simple esters with ethylmagnesium bromide, leading to substituted cyclopropanols in excellent yields.
Comment
Interestingly, in the presence of the titanium catalyst, ethylmagnesium bromide is transformed into an ethylene dianion, which is reactive towards alkylcarboxylic esters.
