DOI: 10.1055/s-00000131

Synfacts

Issue 10 · Volume 15 · October 2019 DOI: 10.1055/s-009-44215

Synform

A148
Zanda, Matteo: SYNFORM ISSUE 2019/10

Synthesis of Natural Products and Potential Drugs

z1089
All PDFs of this category
1089
Total Synthesis of Gymnocin B
1090
Synthesis of (±)-Hirsutene
1091
Synthesis of AZD6738
1092
Synthesis of GDC-0077
1093
Synthesis of (–)-Salinosporamide A
1094
Synthesis of Aspidosperma Alkaloids by a Radical Cyclization Strategy
1095
Total Synthesis of (−)-Nemorosone and (−)-6-epi-Garcimultiflorone A
1096
Synthesis of GSK2981278A
1097
Synthesis of SIPI 6398
1098
Synthesis of M-89
1099
Synthesis of (+)-Dapholdhamine B
1100
Synthesis of Ziresovir
1101
Stereochemical Revision and Total Synthesis of Mytilipin B
1102
Synthesis of Dapagliflozin
1103
Synthesis of a CCR4 Antagonist
1104
Synthesis of ABBC-2222

Synthesis of Heterocycles

z1105
All PDFs of this category
1105
Enantioselective Synthesis of Cyclic Dipeptides by Iridium-Catalyzed Hydrogenation
1106
Rhodium-Catalyzed Synthesis of Chiral Sulfoximines and 1,2-Benzothiazines
1107
Pyridine Synthesis by 6π-3-Azatriene Electrocyclization
1108
Copper-Catalyzed Iodine-Mediated Synthesis of Indolizines
1109
Palladium–NHC Catalyzed Coupling of Organolithium Reagents at Low Temperatures
1110
N-Acetyl-Directed Cyclopropanation of Indoles
1111
Synthesis of Spirocyclic Thiadiazino Quinazolinones
1112
3-Aroylquinolines by a Three-Component Reaction of Anilines, Enaminones, and DMSO
1113
Palladium(II)-Catalyzed Synthesis of Pyrroles from Alkynylimines and Isocyanides
1114
Brønsted Acid Catalyzed Synthesis of α-(3-Indolyl) Ketones
1115
Enantioselective Cyclization of Alkenyl Amides to Polycyclic Dihydroindoles
1116
Photoredox Approach to Fluorinated Pyrrolo[1,2-a][1,5]benzodiazepines
1117
Photoredox-Mediated Pyridonation of (Het)Arenes
1118
Decarboxylative Cross-Coupling of α-Amino Acids and α-Oxy Acids with Aryl Nitriles
1119
Cobalt-Catalyzed Synthesis of Benzoindol-2-ones from Naphthylamides

Synthesis of Materials and Unnatural Products

z1121
All PDFs of this category
1121
Synthesis of Conjugated Nanohoops Containing Antiaromatic Units
1122
Ladies & Gentlemen: The Nanocone
1123
Get Your Chloride Here
1124
Synthesis of Cryptophane-Type Xenon Hosts with Biosensing Application
1125
Emerging from the Flatlands Using Diels–Alder Cycloaddition
1126
3D Aromaticity: Two Wrongs Do Make a Right in Antiaromatic Cyclophanes
1127
Tying the Molecular Knot
1128
Non-Aromatic Superbenzoquinones
1129
Stabilizing Imine-Based COFs by Oxidative Cyclization
1130
New Molecular Machines? Phosphonium Donor-π-Acceptor Dyes with Tunable Dual Emission
1131
When Aufbau Needs to Bow Down: Highly Photostable and Luminescent Donor–Acceptor Organic Radicals
1132
Rebuilding from the Dust: Suzuki–Miyaura Cross-Coupling Using Mechanical Grinding

Metals in Synthesis

z1133
All PDFs of this category
1133
Regio- and Enantioselective Cobalt-Catalyzed Allylic Amination
1134
Decarboxylative Difluoromethylation via Copper Catalysis
1135
Gold-Catalyzed Enantioselective Cyclizations of Enynes through Remote Enantioinduction
1136
NiH-Catalyzed Remote Hydroarylation of Alkenes
1137
α-Arylation of Carboxylic Acids and Secondary Amides
1138
Nickel-Catalyzed Decarboxylative Allylation with C-Centered Nucleophiles
1139
Formation of Tertiary C–F Bonds through Enantioselective Palladium-Catalyzed Cross-Coupling
1140
Palladium-Catalyzed Synthesis of Alkenylated α,β-Unsaturated Lactams
1141
Copper-Catalyzed Enantioselective Alkylation of N-Heterocyclic Michael Acceptors
1142
Synthesis of β-Branched Arylethylamines
1143
The Kulinkovich Reaction
1144
Synthesis of Chiral α‑CF3 Thioethers
1145
Direct Photoredox-Mediated Giese Reactions
1146
Enantioselective Intramolecular Hydroarylation of Enones
1147
Palladium-Catalyzed Synthesis of Enantioenriched Tertiary Nitroalkanes
1148
Aminotrifluoromethylation of Alkenes via Copper Catalysis
1149
Iridium-Catalyzed Regiodivergent Oxyamination of Unactivated Alkenes
1150
Enantioselective Thiocarbonylation of Styrenes
1151
Gold(I)-Catalyzed Stereoselective Cyclization Reactions
1152
Enantioselective Ring-Opening of Cyclic Diaryliodonium Salts
1153
Cobalt-Catalyzed Acylation Using Thiopyridyl Ester Derivatives
1154
Nickel-Catalyzed Decarboxylative Coupling of Carboxylic Acid Esters
1155
Copper-Catalyzed 1,4-Reduction of Vinyl Epoxides and Epoxyenynes
1156
Palladium Catalyzed Atroposelective C–H Functionalization
1157
Enantioselective Copper-Catalyzed SN2′ Substitution on Allylic Phosphates using Allenyl Boronates
1158
Copper-Catalyzed Synthesis of Enantioenriched β-Hydroxy Allenes
1159
CO2-Based Carboxylation of C–F Bonds under Copper Catalysis
1160
A New Reductive Arylation of Redox-Active Sulfones

Polymer-Supported Synthesis

z1161
All PDFs of this category
1161
Enantioselective Michael Addition Using Quinine Adsorbed in Alginate Gel
1162
Intramolecular Cyclization of 2-Allylanilines and 2-Allylphenols on Pd/C
1163
Stille Coupling Catalyzed by Gold Nanoparticles Formed In Situ on Active Carbon
1164
Heterogeneous Tungsten-Catalyzed Synthesis of 2-Azapyrrolizidines
1165
Ferrier Rearrangements Catalyzed by a Magnetic Iron(III) Nanocatalyst
1166
Asymmetric Epoxidation of Allylic Alcohols on Polystyrene-Supported Vanadium
1167
Palladium Nanoparticle Catalyzed Sonogashira Coupling in Water
1168
Hydrogenation of Carbonyl Compounds by Platinum on Ceria–Zirconia
1169
Reduction of Nitroarenes on Goethite-Supported Rhodium Nanoparticles
1170
Deacylation Coupling and Cyclization Catalyzed by a Magnetic Metal–Organic Framework
1171
Cyanation of Terminal Alkynes with Switchable Copper Metal–Organic Frameworks
1172
Suzuki–Miyaura Coupling Catalyzed by Ligand-Stabilized Palladium Nanoparticles
1173
Primary Aniline Synthesis by Dehydrogenative Aromatization on Pd Nanoparticles
1174
Palladium-Free Sonogashira Coupling with Supported Copper Nanoparticles

Organo- and Biocatalysis

z1175
All PDFs of this category
1175
Sulfenylation/Semipinacol Reaction of Di- and Trisubstituted Allylic Alcohols
1176
Dehydrative Annulation of Amines with Carboxylic Acids via PIII/PV Catalysis
1177
Stereoselective Radical Cyclization by Photoexcited Flavoenzymes
1178
Organocatalytic Aldehyde Olefination: Synthesis of α,β-Disubstituted Acrylates
1179
Benzylic Photocarboxylation through C–H Bond Photoactivation
1180
Radical Chain Reaction Catalyzed by Organic Super Electron Donors
1181
Electrophotoredox Coupling Between Arenes and Nitrogen Heteroaromatics
1182
Coordinatively Saturated Phosphorus(V) Species Initiates Silylium Catalysis
1183
Asymmetric Lewis Base-Catalyzed Sulfenoacetalization of Alkenals
1184
Organocatalytic Synthesis of γ-Butyrolactones
1185
The Steglich Esterification

Chemistry in Medicine and Biology

z1187
All PDFs of this category
1187
Binding-Site Hotspot Mapping using Photochemical Proteomics
1188
Structure-Guided Discovery of Selective Mcl-1 Inhibitors
1189
Ethynylphosphonamidates in the Synthesis of Antibody–Drug Conjugates
1190
A Reagent for Doubly Bioorthogonal Cysteine Labeling
1191
Staudinger Ligation in Living Animals
1192
Photocatalytic Defluoroalkylation of Unactivated Trifluoromethylarenes
1193
Targeted Degradation of Extracellular Proteins with ENDTACs
1194
Profiling of Inhibitor-Bound Kinase Complexes
1195
Selenophosph(V)azanes as Transporters and Sensors
1196
Defying the Odds – Drugging KRAS
1197
In vivo Visualization of Copper(II) in the Brain

Peptide Chemistry

z1199
All PDFs of this category
1199
Modified KAHA Ligation for Protein Synthesis
1200
Selenium-Auxiliary-Mediated Chemical Ligation
1201
Sulfide-Mediated Peptide Ligation in Water
1202
Palladium-Catalyzed Hydrogenation of β-Fluoroalkyl β-Amino Acrylic Acids
1203
Stereoselective Synthesis of α-Allyl Amino Esters by Organocatalysis
1204
Formamide-Catalyzed Efficient Amidation and Esterification
1205
Atroposelective Couplings of Indoles with Amino Acid Derivatives
1206
Synthesis of Selenocysteine-Based Peptides
1207
Staudinger Ligation for the Synthesis of Peptides
1208
Cooperative Catalysis for Asymmetric Multicomponent Reactions
1209
Removal of Aminoquinoline Auxiliary from Protected α-Amino Acids

Flow Chemistry

z1211
All PDFs of this category
1211
Ibuprofen in Continuous Flow without Headache
1212
Synthesis of α-CF2H-Substituted Ketones from Styrenes via Photoredox Catalysis in Flow
1213
Three-Step Streamlined Flow Synthesis of Imatinib and Analogues
1214
Continuous-Flow Photochemical Iodoperfluoroalkylation of Alkenes