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Synthesis 2020; 52(12): 1719-1737
DOI: 10.1055/s-0039-1690843
DOI: 10.1055/s-0039-1690843
review
Recent Advances in Photocatalytic Decarboxylative Coupling Reactions in Medicinal Chemistry
Further Information
Publication History
Received: 08 January 2020
Accepted after revision: 08 February 2020
Publication Date:
09 March 2020 (online)
Abstract
This review covers recent advances in decarboxylative photocatalysis applicable to the medicinal chemist. The review is not intended to be exhaustive, but instead is focussed on transformations that could be useful in the synthesis of drug-like compounds in order to highlight the utility of this methodology in the development of new pharmaceutical candidates.
1 Introduction
2 C–C Bond Formation
3 C–N and C–O Bond Formation
4 Fluorination and Trifluoromethylation
5 Hydrodecarboxylation
6 Protein Functionalisation
7 Conclusion
-
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