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Synthesis 2020; 52(09): 1387-1397
DOI: 10.1055/s-0039-1691597
DOI: 10.1055/s-0039-1691597
paper
1,3-Dipolar Cycloaddition of 3-Amino Oxindole-Based Azomethine Ylides and O-Vinylphosphonylated Salicylaldehydes for Diastereoselective Synthesis of Oxindole Spiro-P,N-polycyclic Heterocycles
Authors
We gratefully acknowledge the financial support from Program of Natural Science Foundation of Hainan Province (2019RC215) and Graduate Innovative Research Project of Hainan Normal University (Hsyx2018-25).
Weitere Informationen
Publikationsverlauf
Received: 04. November 2019
Accepted after revision: 21. Januar 2020
Publikationsdatum:
12. Februar 2020 (online)
Abstract
An efficient stereoselective assembly strategy for the construction of pyrrolidin-2,3′-oxindole cis-fused phosphadihydrocoumarins was established. The process involves the condensation of O-vinylphosphonylated salicylaldehydes and 3-amino oxindoles followed by intermolecular cycloaddition with high diastereoselectivity and atom economy.
Key words
3-amino oxindole - azomethine ylide - dipolar cycloaddition - pyrrolidin-2,3′-oxindoles - cis-fused phosphadihydrocoumarins - O-vinylphosphonylated salicylaldehydeSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1691597.
- Supporting Information (PDF)
-
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