Download PDF
Synfacts 2020; 16(03): 0363
DOI: 10.1055/s-0039-1691660
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Chlorofusin Cyclic Peptide Synthesis

Contributor(s):
Hisashi Yamamoto
,
Tomohiro Hattori
Desai P, Pfeiffer SS, Boger DL. * The Scripps Research Institute, La Jolla, USA
Synthesis of the Chlorofusin Cyclic Peptide: Assignment of the Asparagine Stereochemistry.

Org. Lett. 2003;
5: 5047-5050
CrossrefPubMedSearch in Google Scholar
Further Information

Publication History

Publication Date:
18 February 2020 (online)

 
 PDF Download Permissions and Reprints

Key words

chlorofusin - cyclic peptides - coupling reagents - macrocycles

Significance

Cyclic peptides with unique molecular topologies have attracted attention from the fields of biochemistry and medicinal chemistry. In 2003, Boger and co-workers synthesized the cyclic peptide of chlorofusin, consisting of nine amino acid residues.


#

Comment

The nine amino acids were assembled from four subunits. Subsequent cyclization using coupling reagents proceeded smoothly to give the 27-membered macrocycle in a moderate yield.


#
#


   Permissions and Reprints