Ben-Lulu M,
Gaster E,
Libman A,
Pappo D.
* Ben-Gurion University of the Negev, Beer Sheva, Israel
Synthesis of Biaryl-Bridged Cyclic Peptides via Catalytic Oxidative Cross-Coupling
Reactions.
Angew. Chem. Int. Ed. 2020;
DOI:
10.1002/anie.201913305
Key words
oxidative cross-coupling - cyclic peptides - biaryl-bridged peptides - activating
group
Significance
Biaryl-bridged cyclic peptides are becoming more and more important due to their biological
activity. The authors have developed an efficient strategy to synthesize these peptides
by introducing a removable activating group to increase reactivity in the oxidative
cross-coupling step that forms the biaryl unit.
Comment
Although the authors have prepared some natural and nonnatural biaryl-bridged cyclic
peptides in moderate total yields, this approach with a remarkable activating group
(t-Bu) might have more synthetic uses.
