Cyclic Peptides Synthesis with the Assistance of a Removable Activating Group

Key words

oxidative cross-coupling - cyclic peptides - biaryl-bridged peptides - activating group

Significance

Biaryl-bridged cyclic peptides are becoming more and more important due to their biological activity. The authors have developed an efficient strategy to synthesize these peptides by introducing a removable activating group to increase reactivity in the oxidative cross-coupling step that forms the biaryl unit.

Comment

Although the authors have prepared some natural and nonnatural biaryl-bridged cyclic peptides in moderate total yields, this approach with a remarkable activating group (t-Bu) might have more synthetic uses.