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Synfacts 2020; 16(03): 0245
DOI: 10.1055/s-0039-1691678
DOI: 10.1055/s-0039-1691678
Synthesis of Natural Products and Potential Drugs
Total Synthesis of Swinhoeisterol A, Dankasterones A and B, and Periconiastone A
Further Information
Publication History
Publication Date:
18 February 2020 (online)
Key words
swinhoeisterol A - dankasterone A - dankasterone B - periconiastone A - radical rearrangement - skeleton rearrangement![](https://www.thieme-connect.de/media/synfacts/202003/i_c006_s1_10-1055_s-0039-1691678.gif)
Significance
Heretsch and co-workers report the total synthesis of a number of structurally intriguing natural products from a common intermediate. The concise synthesis is enabled by the strategic application of a switchable alkoxy radical rearrangement.
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Comment
Ergosterol is transformed by a known route to cyclopropane A. Two different conditions were developed to lead selectively to B or C. Those advanced intermediates could subsequently be converted into four different complex natural products.
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![](https://www.thieme-connect.de/media/synfacts/202003/i_c006_s1_10-1055_s-0039-1691678.gif)