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Synlett 2020; 31(09): 838-844
DOI: 10.1055/s-0039-1691738
DOI: 10.1055/s-0039-1691738
account
C–H Insertion Reactions of Donor/Donor Carbenes: Inception, Investigation, and Insights
Funding for this work has come from Fundación Ramon Areces (postdoctoral fellowship for Dr. Marcos González-Lopéz), CAPES (Coordenação de Aperfeicoamento de Pessoal de Nível Superior; postdoctoral fellowship for Dr. Cristian Soldi), the American Chemical Society Petroleum Research Fund (ACS PRF; 53767-ND1), and the National Institutes of Health (NIH/NIGMS; R01 GM124234).Further Information
Publication History
Received: 06 December 2019
Accepted after revision: 24 January 2020
Publication Date:
10 March 2020 (online)
Abstract
Insertion reactions of donor/donor carbenes have emerged from obscurity to become a versatile method for the synthesis of a variety of cyclic structures with excellent control of diastereo- and enantioselectivity. This Account describes the origin of this project as part of a natural product synthesis and the ensuing decade of reaction development that has resulted in new asymmetric methods as well as intriguing tangential observations.
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