PDF herunterladen
Semin Neurol 2020; 40(01): 160-164
DOI: 10.1055/s-0039-3402740
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Mal de Debarquement Syndrome

Kamala Saha
1   Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona
,
Yoon-Hee Cha
2   Department of Neurology, University of Minnesota, Minneapolis, Minnesota
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
27. Januar 2020 (online)

    Lizenzen und Reprints

Abstract

Mal de debarquement syndrome (MdDS) is a disorder of persistent vertigo characterized by a feeling of oscillation such as rocking, bobbing, or swaying. It is triggered by passive motion, typically by exposure to water, air, or land transportation. This syndrome affects middle-aged individuals who are predominantly women. MdDS presents as a balance disorder that carries significant risk of morbidity due to both the direct effects of balance impairment and associated symptoms of fatigue, cognitive slowing, and visual motion intolerance. The Barany Society will be publishing criteria for diagnosing persistent MdDS. In addition, more insight has been gained into the pathophysiology of MdDS, with current hypotheses pointing to a cerebral and cerebellar basis. Treatments have expanded beyond medication trials, and now include the use of noninvasive brain stimulation and readaptation of the vestibulo-ocular reflex.

Keywords

mal de debarquement syndrome - persistent oscillating vertigo - disembarkment syndrome
 

  • References

  • 1 Adams F. The genuine works of Hippocrates translated from the Greek. Syndenham Soc 1822; 2: 725
    PubMedSuche in Google Scholar
  • 2 Huppert D, Benson J, Brandt T. A historical view of motion sickness-a plague at sea and on land, also with military impact. Front Neurol 2017; 8: 114
    PubMedSuche in Google Scholar
  • 3 Whittie J. An Exact Diary of the Late Expedition of His Illustrious Highness the Price of Orange, 1689. Bradford on Avon, UK: Ex Libris Press; 1986
    Suche in Google Scholar
  • 4 Reason J, Brand J. Motion Sickness. Academic Press; 1975
    Suche in Google Scholar
  • 5 Brown JJ, Baloh RW. Persistent mal de debarquement syndrome: a motion-induced subjective disorder of balance. Am J Otolaryngol 1987; 8 (04) 219-222
    CrossrefPubMedSuche in Google Scholar
  • 6 Stoffregen TA, Chen FC, Varlet M, Alcantara C, Bardy BG. Getting your sea legs. PLoS One 2013; 8 (06) e66949
    CrossrefPubMedSuche in Google Scholar
  • 7 Cohen H. Mild mal de debarquement after sailing. Ann N Y Acad Sci 1996; 781: 598-600
    CrossrefPubMedSuche in Google Scholar
  • 8 Nachum Z, Shupak A, Letichevsky V. , et al. Mal de debarquement and posture: reduced reliance on vestibular and visual cues. Laryngoscope 2004; 114 (03) 581-586
    CrossrefPubMedSuche in Google Scholar
  • 9 Gordon CR, Spitzer O, Doweck I, Melamed Y, Shupak A. Clinical features of mal de debarquement: adaptation and habituation to sea conditions. J Vestib Res 1995; 5 (05) 363-369
    CrossrefPubMedSuche in Google Scholar
  • 10 Hain TC, Cherchi M. Mal de débarquement syndrome. Handb Clin Neurol 2016; 137: 391-395
    PubMedSuche in Google Scholar
  • 11 Cha YH, Brodsky J, Ishiyama G, Sabatti C, Baloh RW. Clinical features and associated syndromes of mal de debarquement. J Neurol 2008; 255 (07) 1038-1044
    CrossrefPubMedSuche in Google Scholar
  • 12 Bisdorff A, Von Brevern M, Lempert T, Newman-Toker DE. Classification of vestibular symptoms: towards an international classification of vestibular disorders. J Vestib Res 2009; 19 (1-2): 1-13
    CrossrefPubMedSuche in Google Scholar
  • 13 Cha YH, Cui YY, Baloh RW. Comprehensive clinical profile of mal de debarquement syndrome. Front Neurol 2018; 9: 261
    CrossrefPubMedSuche in Google Scholar
  • 14 Cha YH. Mal de debarquement. Semin Neurol 2009; 29 (05) 520-527
    Thieme ConnectPubMedSuche in Google Scholar
  • 15 Dai M, Cohen B, Smouha E, Cho C. Readaptation of the vestibulo-ocular reflex relieves the mal de debarquement syndrome. Front Neurol 2014; 5: 124
    CrossrefPubMedSuche in Google Scholar
  • 16 Grommes C, Conway D. The stepping test: a step back in history. J Hist Neurosci 2011; 20 (01) 29-33
    CrossrefPubMedSuche in Google Scholar
  • 17 Dai M, Cohen B, Cho C, Shin S, Yakushin SB. Treatment of the mal de debarquement syndrome: a 1-year follow-up. Front Neurol 2017; 8: 175
    CrossrefPubMedSuche in Google Scholar
  • 18 Cha YH, Cui Y. Rocking dizziness and headache: a two-way street. Cephalalgia 2013; 33 (14) 1160-1169
    CrossrefPubMedSuche in Google Scholar
  • 19 Staab JP, Eckhardt-Henn A, Horii A. , et al. Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): consensus document of the committee for the Classification of Vestibular Disorders of the Bárány Society. J Vestib Res 2017; 27 (04) 191-208
    CrossrefPubMedSuche in Google Scholar
  • 20 Mucci V, Canceri JM, Brown R. , et al. Mal de debarquement syndrome: a survey on subtypes, misdiagnoses, onset and associated psychological features. J Neurol 2018; 265 (03) 486-499
    CrossrefPubMedSuche in Google Scholar
  • 21 Macke A, LePorte A, Clark BC. Social, societal, and economic burden of mal de debarquement syndrome. J Neurol 2012; 259 (07) 1326-1330
    CrossrefPubMedSuche in Google Scholar
  • 22 Arroll M, Attree E, Cha Y, Dancey C. The relationship between symptom severity, stigma, illness intrusiveness and depression in mal de debarquement syndrome. J Health Psychol 2016; 21 (07) 1339-1350
    CrossrefPubMedSuche in Google Scholar
  • 23 Cha YH. Mal de debarquement syndrome: new insights. Ann N Y Acad Sci 2015; 1343 (01) 63-68
    CrossrefPubMedSuche in Google Scholar
  • 24 Cha YH, Chakrapani S, Craig A, Baloh RW. Metabolic and functional connectivity changes in mal de debarquement syndrome. PLoS One 2012; 7 (11) e49560
    CrossrefPubMedSuche in Google Scholar
  • 25 Furman JM, Balaban CD, Jacob RG, Marcus DA. Migraine-anxiety related dizziness (MARD): a new disorder?. J Neurol Neurosurg Psychiatry 2005; 76 (01) 1-8
    CrossrefPubMedSuche in Google Scholar
  • 26 Lempert T, Olesen J, Furman J. , et al. Vestibular migraine: diagnostic criteria. J Vestib Res 2012; 22 (04) 167-172
    CrossrefPubMedSuche in Google Scholar
  • 27 Fife TD. Migraine associated vertigo: a common but difficult-to-define disorder. Pract Neurol 2009; 9: 27-33
    CrossrefPubMedSuche in Google Scholar
  • 28 Lempert T. Vestibular migraine. Semin Neurol 2013; 33 (03) 212-218
    Thieme ConnectPubMedSuche in Google Scholar
  • 29 Saha KC, Fife TD. Mal de débarquement syndrome: review and proposed diagnostic criteria. Neurol Clin Pract 2015; 5 (03) 209-215
    CrossrefPubMedSuche in Google Scholar
  • 30 Dickson CT, Magistretti J, Shalinsky M, Hamam B, Alonso A. Oscillatory activity in entorhinal neurons and circuits. Mechanisms and function. Ann N Y Acad Sci 2000; 911: 127-150
    PubMedSuche in Google Scholar
  • 31 Hafting T, Fyhn M, Molden S, Moser MB, Moser EI. Microstructure of a spatial map in the entorhinal cortex. Nature 2005; 436 (7052): 801-806
    PubMedSuche in Google Scholar
  • 32 Egorov AV, Hamam BN, Fransén E, Hasselmo ME, Alonso AA. Graded persistent activity in entorhinal cortex neurons. Nature 2002; 420 (6912): 173-178
    PubMedSuche in Google Scholar
  • 33 Fransén E, Tahvildari B, Egorov AV, Hasselmo ME, Alonso AA. Mechanism of graded persistent cellular activity of entorhinal cortex layer v neurons. Neuron 2006; 49 (05) 735-746
    CrossrefPubMedSuche in Google Scholar
  • 34 Cha YH, Cui Y, Baloh RW. Repetitive transcranial magnetic stimulation for mal de debarquement syndrome. Otol Neurotol 2013; 34 (01) 175-179
    CrossrefPubMedSuche in Google Scholar
  • 35 Cha YH, Deblieck C, Wu AD. Double-blind sham-controlled cross-over trial of repetitive transcranial magnetic stimulation for mal de debarquement syndrome. Otol Neurotol 2016; 37 (06) 805-812
    CrossrefPubMedSuche in Google Scholar
  • 36 Cha YH, Urbano D, Pariseau N. Randomized single blind sham controlled trial of adjunctive home-based tDCS after rTMS for mal de debarquement syndrome: safety, efficacy, and participant satisfaction assessment. Brain Stimul 2016; 9 (04) 537-544
    CrossrefPubMedSuche in Google Scholar
  • 37 Ding L, Shou G, Yuan H, Urbano D, Cha YH. Lasting modulation effects of rTMS on neural activity and connectivity as revealed by resting-state EEG. IEEE Trans Biomed Eng 2014; 61 (07) 2070-2080
    CrossrefPubMedSuche in Google Scholar
  • 38 Yuan H, Shou G, Urbano D, Ding L, Cha YH. Resting state functional connectivity signature of treatment effects of rTMS in mal de debarquement syndrome. Brain Connect 2017; 7: 617-626
    CrossrefPubMedSuche in Google Scholar
  • 39 Cha YH, Shou G, Gleghorn D, Doudican BC, Yuan H, Ding L. Electrophysiological signatures of intrinsic functional connectivity related to rTMS treatment for mal de debarquement syndrome. Brain Topogr 2018; 31 (06) 1047-1058
    CrossrefPubMedSuche in Google Scholar
  • 40 Ghavami Y, Haidar YM, Ziai KN. , et al. Management of mal de debarquement syndrome as vestibular migraines. Laryngoscope 2017; 127 (07) 1670-1675
    CrossrefPubMedSuche in Google Scholar