Download PDF
Synfacts 2020; 16(09): 1125
DOI: 10.1055/s-0040-1705851
Peptide Chemistry

A Novel Reagent for tert-Butoxycarbonylation of Amino Acids

Contributor(s):
Hisashi Yamamoto
,
An Wu
Ouchi H, Saito Y, Yamamoto Y, Takahata H. * Tohoku Pharmaceutical University, Sendai, Japan
1-tert-Butoxy-2-tert-butoxycarbonyl-1,2-dihydroisoquinoline: A Novel and Chemoselective tert-Butoxycarbonylation Reagent.

Org. Lett. 2002;
4: 585-587
CrossrefPubMedSearch in Google Scholar
› Further Information
 
 PDF Download Permissions and Reprints

Key words

butoxycarbonylation - amino acids - chemoselectivity - isoquinolines

Significance

Boc-protected amino acids are important because of their good resistance in peptide synthesis. The authors developed (BBDI) as an alternative to the conventional tert-butoxycarbonylating reagent di-tert-butyl dicarbonate for the synthesis of Boc-protected α-amino acids.


#

Comment

With the tert-butoxycarbonylating reagent BBDI, various Boc-protected α-amino acids can be synthesized from amino acid ester hydrochlorides in excellent yields.


#
#

Publication History

Article published online:
18 August 2020

© 2020. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany


   Permissions and Reprints