Knauer S,
*,
Koch N,
Uth C,
Meusinger R,
Avrutina O,
Kolumar H.
*
Sulfotools GmbH, Darmstadt and Technische Universität Darmstadt, Germany
Sustainable Peptide Synthesis Enabled by a Transient Protecting Group.
Angew. Chem. Int. Ed. 2020;
59: 12984-12990
Key words
solid-phase synthesis - peptide synthesis - aqueous media - protecting group - fluorescence
Significance
Peptide synthesis in water as the solvent is underdeveloped. The author have developed a solid-phase peptide synthesis (SPPS) in aqueous media by using a new 2,7-disulfo-9-fluorenylmethoxycarbonyl (Smoc) N-protecting group.
Comment
The authors developed the Smoc group as an N-protecting group. The Smoc group, which is fluorescent, can be used for SPPS in aqueous media and is easily removed.
