Synthesis 2021; 53(08): 1489-1494
DOI: 10.1055/s-0040-1705961
paper

Nickel-Catalyzed Reductive Allylation of Aldehydes with Allyl Acetates

Hiroyuki Suzuki
,
Eiji Yamaguchi
,
Akichika Itoh
The work was financially supported by the OGAWA Science and Technology Foundation (EY) and a Ministry of Education, Culture, Sports, Science, and Technology (MEXT) Grant-in-Aid for Young Scientists (Grant Number 18K14871) (to E.Y.).


Abstract

Carbonyl allylation reactions constitute an important step in the formation of carbon–carbon reactions, and involve various related reactions that chiefly use allylmetal reagents. This report presents a nickel-catalyzed carbonyl allylation reaction using allyl acetate, which produces homoallyl alcohols in moderate to good yields, as an efficient methodology under reductive coupling conditions.

Supporting Information



Publication History

Received: 01 September 2020

Accepted after revision: 01 October 2020

Article published online:
02 December 2020

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