Gagnon P,
Huang X,
Therrien E,
Keillor JW.
*
Université de Montréal, Canada
Peptide Coupling of Unprotected Amino Acids through in situ
p-Nitrophenyl Ester Formation.
Tetrahedron Lett. 2002;
43: 7717-7719
Key words
peptide bond formation - nitrophenyl esters - amino acids
Significance
Reactive amino acid phenyl esters have been used in peptide synthesis. In 2002, Keillor and co-workers reported a method for peptide bond formation between p-nitrophenyl esters and unprotected amino acids in aqueous solution.
Comment
By using p-nitrophenyl esters formed in situ, various dipeptides or tripeptides were synthesized without classical peptide-coupling reagents. The yields of the target peptides were moderate to excellent.
