DOI: 10.1055/s-00000131

Synfacts

Issue 01 · Volume 17 · January 2021 DOI: 10.1055/s-010-50049

Synform

A1
Zanda, Matteo: SYNFORM ISSUE 2021/01

Synthesis of Natural Products and Potential Drugs

z0001
All PDFs of this category
0001
Synthesis of HIV Integrase Inhibitor MK-1376
0002
Synthesis of BAY 1214784
0003
Synthesis of (±)-Leonuketal
0004
Synthesis of (–)-Spiroviolene
0005
Synthesis of GDC-0310
0006
Synthesis of Bruton’s Tyrosine Kinase Inhibitor GDC-0852
0007
Cyanoamidine Cyclization Approach to Remdesivir’s Nucleobase
0008
Total Synthesis of (+)-Beshanzuenone D and (+)-Abiespiroside A
0009
Total Syntheses of (+)-Waihoensene
0010
A Short Synthesis of Molnupiravir
0011
Synthesis of the Corey Lactone and Latanoprost
0012
Synthesis of MK-2947
0013
Synthesis of CD73 Inhibitor AB680
0014
Total Synthesis of (−)-Mitrephorone A
0015
Synthesis of GNE-834
0016
Route to Remdesivir’s Nucleobase via N-Amination of 2-Cyanopyrrole
0017
Asymmetric Synthesis of an Imidazoline Proteasome Modulator
0018
Enantioselective Total Synthesis of (+)-Stemofoline
0019
Total Synthesis of (±)-Lysergic Acid
0020
Synthesis of Lamivudine

Synthesis of Heterocycles

z0021
All PDFs of this category
0021
C–H Functionalization of Quinolines, Isoquinolines, and Pyridines by N-Alkenoxyhetareniums
0022
Synthesis of 2-Arylindoles by Iridium(III)-Catalyzed Sequential Annulations
0023
N-Alkylation of Hetarenes through Electrochemical Oxidation of Carboxylic Acids
0024
Gram-Scale Synthesis of Cyclopropane-Fused Saturated Heterocycles Featuring a Trifluoroborate Moiety
0025
Decarboxylative Heteroannulation Route to Phenanthridin-6-ones
0026
Synthesis of Angular and Linear Heteroannulated Furochromenopyridines

Synthesis of Materials and Unnatural Products

z0027
All PDFs of this category
0027
O2 Will Do
0028
A Golden Opportunity to Expand the Scope of Late-Transition-Metal-Mediated Polycondensations
0029
Having it all: A One-Step, Three-Component, Regioselective Synthesis of Cationic Azahelicenes
0030
Ionic-Liquid-Assisted Thiophene Formation from Xanthantes and Bromoenynes
0031
Unexpected Formation of Diallenes
0032
A Curved Member of the s-Indacenodifluorene Series
0033
Trapping Aryne Atropisomers
0034
One-Pot Synthesis of a Boron-Doped Polycyclic Aromatic Hydrocarbon
0035
Nitrogen-Doped Coronenes by Rhodium-Catalyzed C–H Activation
0036
Cycloparaphenylenes with a Twist
0037
Carbamate-Promoted Carboxylation: A High-Pressure Route to Sustainability
0038
A Choosy Arylene Macrocycle that Likes to Fly Solo

Metals in Synthesis

z0039
All PDFs of this category
0039
Enantioselective Pd-Catalyzed Trimethylenemethane Cycloadditions of All-Carbon 1,4-Dipoles
0040
Enantioselective Dual Nickel- and Photocatalyzed C(sp3)–H α-Acylation of N-Alkyl Benzamides
0041
Enantioselective Catalytic Hydroamination of Internal Alkenes
0042
Palladium-Catalyzed Cross-Coupling of Aryl Halides and Hydrazine
0043
Asymmetric [4+1] and [5+1] Annulation of Arenes and 1,3-Enynes via Rhodium(III)-Catalysis
0044
Palladium-Catalyzed Hydroamidation of 1,3-Diynes
0045
Iron-Catalyzed Intramolecular Amidation
0046
Ruthenium-Catalyzed Formation of 1,3-Enynes and 1-Chloro-1,3-enynes
0047
Dynamic Kinetic Resolution of Atropisomeric Anilides via Palladium-Catalyzed C–H Olefination
0048
trans-Selective and Switchable Arene Hydrogenation of Phenol Derivatives
0049
Enantioconvergent Copper-Catalyzed Cross-Coupling of Racemic Alkyl Halides with Boronate Esters
0050
Nickel(II)-Catalyzed Intramolecular Oxygen Transfer of N-Vinyl Nitrones Generating Substituted Pyridines
0051
Light-Mediated, Iridium-Catalyzed Interrupted [2+2] Cycloaddition
0052
Nickel-Catalyzed Hydrofluorination of Alkenes
0053
Radical Hydrogenation of Alkenes
0054
Zinc-Catalyzed Cascade Cyclization of N-Propargylanilines and Aziridines
0055
Enantiodifferentiating Oxidation of Cyclic Ethers Enabled by Manganese Catalysis
0056
Copper- and DMAP-Catalyzed Formation of Alkyl, Alkenyl and Aryl Amines
0057
Three-Component Coupling Towards Ethylphosphine Oxides
0058
Synthesis of Esters from Organic Halides and Oxygen by NHC-Catalysis
0059
Palladium Photocatalysis for Alkylation of Simple Arenes
0060
Cobalt-Catalyzed Cross Coupling of Arylnitriles and Arylhalides
0061
Photocatalyzed Radical Sulfonation-Cyclization Involving a 1,5-Hydrogen Atom Transfer Process
0062
Chromium-Catalyzed Preparation of Skipped Dienes from Allenes
0063
Photocatalytic α‑Alkylation of Amines with Alkyl Halides
0064
Enantioselective Alkylation of Azoles
0065
Chromium-Catalyzed Nozaki–Hiyama–Kishi Reaction
0066
Preparation of Optically Enriched Tertiary Alcohols from Grignard Reagents

Polymer-Supported Synthesis

z0067
All PDFs of this category
0067
Titania-Promoted Hydroalkylation of Electron-Deficient Olefins
0068
Cobalt Nanoparticle-Catalyzed Aerobic C–C Bond Cleavage in Alcohols
0069
The Huisgen Cycloaddition in Water by Using Polydiacetylene Micelles Containing a Cu(II) Complex
0070
Intermolecular Stetter Reaction Catalyzed by Copper-Doped g-C3N4 in H2O under LED Irradiation
0071
C–H Alkenylation of Quinoline N-Oxides with a Polystyrene Resin-Supported Palladium Catalyst
0072
Photocatalytic Anaerobic Oxidation of Alcohols without Added Oxidants by Using Pt/g-C3N4
0073
Regioselective Hydrosilylation of Alkynes on Ligand-Modified Nickel/Alumina
0074
Synthesis and Application of Metalated 2D-Hydrazone-Linked COFs for Cross-Coupling Reactions
0075
One-Pot Reductive Amination of Aldehydes with Nitroarenes on a Nickel/Nickel Oxide Composite
0076
N-Arylation with Copper(I) Iodide and Single-Atomic Iron on Graphitic Carbon Nitride
0077
Ir–Ni Dual-Photocatalyst Supported on a Flexible Polymer for C–S, C–O, and C–C Cross-Coupling

Organo- and Biocatalysis

z0079
All PDFs of this category
0079
Identification of the First Enzyme-Catalyzed Alder–Ene Reaction
0080
Organophosphate-Catalyzed Intramolecular Aldolization Toward a Seven-Membered Ring
0081
Enantioselective Formation of Azetidines by a Chiral Thioxanthone-Mediated Aza-Paternò–Büchi Reaction
0082
Asymmetric Functionalization of 2-Vinylazaarenes by Cooperative Photoredox and Brønsted Acid Catalysis
0083
Enantio- and Diastereoselective Michael Addition: Alkylation Reactions on α,β-Unsaturated Carbonyls
0084
Photochemical C−H Hydroxyakylation of N-Heteroaromatics with Aldehydes
0085
A Polymer Nanoparticle Combines Two Catalysts: Cooperative Catalysis by a Single Molecule
0086
Phosphine-Catalyzed Intermolecular Acylfluorination of Electron-Deficient Alkynes
0087
Photoactivated Giese-Type Additions Promoted by NADH
0088
Ambiphilic Carbene Mimicks Transition-Metal Catalysts in the Activation of Carbon Monoxide
0089
Silylium Asymmetric Counteranion-Directed Catalysis for the Nazarov Cyclization via Anion Binding

Chemistry in Medicine and Biology

z0091
All PDFs of this category
0091
Teaching Old Clicks New Tricks
0092
Serine-Selective Bioconjugation
0093
Morpholine Analogues of Zampanolide
0094
A Fluorogenic Probe for the Detection of Sphingosine
0095
A Mild Method to Access Various Sulfur(VI)-Fluorides
0096
Selective Electrochemical Benzylic C–H Functionalization
0097
A Protecting Group Orchestration Enables Modular Access to Libraries of Heparan Sulfate Oligosaccharides
0098
A Silicon-Based Pain Killer ‘Sila-Ibuprofen’
0099
Versatile Thermoreversible Nucleic Acid Caging
0100
Bright and Orthogonal NanoLuc Substrates
0101
Sarin and Other G-Series Nerve Agents
0102
Click-Chemistry Based Enrichment Strategy Extends the Detectable Metabolome in LC-HRMS/MS Analysis

Peptide Chemistry

z0103
All PDFs of this category
0103
Anhydride-Mediated Peptide Synthesis with C-Terminal Unprotected N-Methylamino Acids
0104
Rhodium-Catalyzed C–H Olefination of Tryptophan Residues
0105
Palladium-Catalyzed Acylation of Tyrosine-Containing Peptides
0106
γ-Amino Acids Synthesis from meso-Glutaric Anhydrides Mediated by Polystyrene-Bound Hünig’s Base
0107
Hydroxy-Directed Diboronic Acid Anhydride-Catalyzed Peptide Synthesis
0108
Azetidine-Based Stereoselective Amino Acid Synthesis
0109
Nickel-Catalyzed Four-Component Coupling Reaction
0110
β2,2-Amino Acid Synthesis from Ketenes and N,O-Acetals
0111
Peptide Bond Formation by Using p-Nitrophenyl Esters

Flow Chemistry

z0113
All PDFs of this category
0113
Continuous Flow Synthesis of a Lamivudine Intermediate
0114
Metalation in Flow for the Synthesis of Highly Functionalized Unsaturated Compounds
0115
Continuous-Flow Synthesis and Application of Nitrogen Transfer Agent Chloramine
0116
thia-Diels–Alder Reaction in Continuous Flow Using Photochemically Generated Thioaldehydes
0117
Continuous-Flow Photoisomerization–Cyclization Process for Quinoline Synthesis
0118
Continuous Cryogenic Lithium–Halogen Exchange
0119
Synthesis of Remdesivir
0120
Continuous Flow Photo-oxidation of Cyclopentadiene