Cysteine-Catalyzed Peptide Synthesis in Neutral Water

Key words

cysteine peptides - catalytic peptide ligation - aqueous media

Significance

Cysteine is very attractive due to its high reactivity as a nucleophile. The authors found that acylated cysteine can be synthesized in a prebiotic approach and used as a catalyst in the catalytic peptide ligation pathway to prepare oligopeptides.

Comment

With the cysteine as a catalyst, various dipeptides can be synthesized in neutral water. When 3-mercaptopropionic acid was used instead of cysteine, oligopeptides could also be prepared in a similar thiol-catalyzed peptide-ligation manner. The yields of the target peptides are moderate to good.

Publikationsverlauf

Artikel online veröffentlicht:
20. Januar 2021