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Synfacts 2021; 17(03): 0347
DOI: 10.1055/s-0040-1706129
Peptide Chemistry

Rhodium-Catalyzed Formation of Disulfide Bonds in Water

Contributor(s):
Hisashi Yamamoto
,
An Wu
Arisawa M, *, Fukumoto K, Yamaguchi M. Tohoku University, Sendai, Japan
Rhodium-Catalyzed Oxidation of Unprotected Peptide Thiols to Disulfides with Oxygen in Water.

ACS Catal. 2020;
10: 15060-15064
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Key words

cysteine peptides - rhodium catalysis - disulfides - oxidation

Significance

The disulfide bond is widely found in peptides and proteins, and it is important for the formation of the structures of proteins. The authors report a rhodium-catalyzed oxidation reaction to form disulfide bonds in water.


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Comment

Various peptide disulfides can be synthesized in water by using a rhodium(III) catalyst. No protecting groups are needed for these peptides in the reactions. The yields of the products are almost quantitative.


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Publication History

Article published online:
16 February 2021

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