Arisawa M,
*,
Fukumoto K,
Yamaguchi M.
Tohoku University, Sendai, Japan
Rhodium-Catalyzed Oxidation of Unprotected Peptide Thiols to Disulfides with Oxygen in Water.
ACS Catal. 2020;
10: 15060-15064
DOI:
10.1021/acscatal.0c04799
Key words
cysteine peptides - rhodium catalysis - disulfides - oxidation
Significance
The disulfide bond is widely found in peptides and proteins, and it is important for the formation of the structures of proteins. The authors report a rhodium-catalyzed oxidation reaction to form disulfide bonds in water.
Comment
Various peptide disulfides can be synthesized in water by using a rhodium(III) catalyst. No protecting groups are needed for these peptides in the reactions. The yields of the products are almost quantitative.
