DOI: 10.1055/s-00000131

Synfacts

Issue 03 · Volume 17 · March 2021 DOI: 10.1055/s-011-50344

Synform

A34
Zanda, Matteo: SYNFORM ISSUE 2021/03

Synthesis of Natural Products and Potential Drugs

z0235
All PDFs of this category
0235
Synthesis of a BACE1 Inhibitor
0236
Synthesis of Molnupiravir from Uridine
0237
Total Synthesis of (–)-Berkelic Acid
0238
Synthesis of Pyrido[2,3-b]indoles Targeting DNA Gyrase and Topisomerase IV
0239
Collective Total Synthesis of Casbane Diterpenes: One Strategy, Multiple Targets
0240
Synthesis of Pamiparib
0241
Synthesis of (±)-Rubiginosins A, D, and G
0242
Synthesis of CC-90011
0243
Synthesis of AZD9833
0244
Synthesis of Daridorexant
0245
Synthesis of (±)-Lyconesidine B
0246
Synthesis of BMS-986144
0247
PIM Kinase Inhibitor
0248
Total Synthesis of (+)-Rumphellclovane E
0249
Synthesis of Vixotrigine
0250
Synthesis of Chitinase Inhibitor OATD-01
0251
Total Synthesis of (±)-Strychnine
0252
Total Synthesis of (–)-Cepharamine
0253
Synthesis of Brensocatib (AZD7986)

Synthesis of Heterocycles

z0255
All PDFs of this category
0255
Thermally Promoted Synthesis of β-Lactam Derivatives
0256
Rhodium-Catalyzed Synthesis of 1H‑Indole-2,3-dicarboxylates from Arylhydrazines and Maleates
0257
Enzymatic Syntheses of Tryptophan Analogues and Incorporation in Biocatalytic Cascades
0258
Increasing the 3D-Character of Heterocyclic Systems through Hydrogenation
0259
Diastereoselective Atom-Economical Synthesis of Dihydropyrans
0260
Rhodium-Catalyzed Synthesis of Chiral Hydrophenanthridinones
0261
Rhodium-Catalyzed Synthesis of Chiral 3,4-Fused Tricyclic Indoles
0262
Rhodium-Catalyzed Synthesis of 1,3-Benzodiazepines
0263
One-Pot Condensation to Tricyclic Azepines
0264
Synthesis of 1,2,4-Triazoles by Annulation of Nitriles with Hydrazines
0265
Cascade Reaction for the Enantioselective Synthesis of Pyrrolizidones
0266
Rhodium-Catalyzed C–H Activation To Form Macrolactams

Synthesis of Materials and Unnatural Products

z0267
All PDFs of this category
0267
How Many Sulfurs are Enough? A Tuning Study on [1,3]-Dioxolo[4.5-f]benzodioxole (DBD) Dyes
0268
Mechanochemical Synthesis of Pilar[5]quinone-Derived Porous Polymers
0269
NHC-Catalyzed Benzoin Condensation for Access to New Cyclotetrabenzoins
0270
Light-Mediated Polymerization Switch
0271
Making a Strong Binder Weak
0272
Reductive Thiolation of Organic Halides via Nickel-Catalyzed Cross-Coupling
0273
Facile Metal-Free Synthesis of Polyaryl-Substituted Pyrroles
0274
Sulfur Alchemy: Exotic Aromatics from Thiophenes
0275
Heavy Indoles: Synthesis of Benzo[b]arsoles
0276
EE-ZZ Access to Azobenzene-Based Macrocycles
0277
Synthesis of Imide-Selenophene Based Polymers
0278
A Feast of πs

Metals in Synthesis

z0279
All PDFs of this category
0279
Regioselective Iron-Catalyzed 1,2-Diamination of Unactivated Alkenes
0280
Triazenyl Alkynes for the Synthesis of β-Amino Amides
0281
Ruthenium-Catalyzed Hydrogenation of Thioesters
0282
Aniline Oxidation for Synthesis of Azo- and Azoxybenzenes
0283
Copper-Catalyzed Synthesis of β-Boryl Amides from Alkenes
0284
Chemoselective Synthesis of Vinylcyclobutanes via Rh-Catalyzed Ring Opening of Vinylcyclopropanes
0285
Cobalt-Catalyzed Enantioselective Hydroalkylation of Cyclopropenes with Cyclopropanols
0286
Palladium-Catalyzed Acylation of Indolines using 1,2-Dicarbonyls
0287
Ruthenium-Catalyzed Electrochemical Synthesis of Isoquinolines
0288
Copper-Catalyzed Formation of Aryl Ethers
0289
Aziridination of Fluorinated Olefins
0290
Acridinium Photocatalysts for C–O Bond Cleavage of Diaryl Ethers
0291
Redox-Neutral Manganese-Catalyzed Silylation of Alkenes
0292
Enantioselective Copper-Catalyzed Allylation of Prochiral Geminal Diborylalkanes
0293
Palladium-Catalyzed C(sp3)–H Allylation of 4-Alkylpyridines
0294
Preparation of Arylated gem-Difluoroalkenes
0295
Light-Mediated Radical α-Arylation of Amides
0296
Enantioselective Rh-Catalyzed Asymmetric Allylation/Tschitschibabin Reaction Sequence
0297
Iridium-Catalyzed Enantioselective β-C(sp3)–H Borylation of Amides
0298
Difluoromethylation of Enol Acetates
0299
Nickel-Catalyzed Carboalkenylation of 1,3-Dienes
0300
Copper-Catalyzed Enantioselective Aminoalkynylation of Styrenes
0301
Photoredox- and Nickel-Catalyzed Phosphonylation of Aryl Halides
0302
Enantioselective Preparation of Chiral 2-Substituted Propanamides
0303
Convergent Synthesis of Complex Alkyl Boronates
0304
Nickel-Catalyzed Dynamic Kinetic Deoxyarylation of Benzylic Alcohols by Cross-Coupling
0305
1,2-Dialkylation of Substituted Acrylates Enabled by Photoredox Chemistry
0306
Double Functionalization of Alkenes via C–H Activation
0307
Larock Indole Synthesis

Polymer-Supported Synthesis

z0309
All PDFs of this category
0309
Photoredox C–O Cross Coupling of Aryl Halides and Alcohols on Nickel-Coordinated Carbon Nitride
0310
Carboxylative Cyclization of Propargylic Alcohols on a Vanadium–Copper Metal–Organic Framework
0311
Photocatalytic Heck Reaction on a Graphene Oxide-Immobilized Bis(terpyridine)ruthenium(II) Complex
0312
Cadmium Sulfide Quantum Dot-Promoted C–C Coupling of Benzylic Alcohols
0313
Zirconium–Palladium Intermetallic Nanocatalyst for Suzuki–Miyaura Cross-Coupling
0314
Zinc Mediated Defluorinative Alkylation of α-(Trifluoromethyl)styrenes
0315
Suzuki–Miyaura Coupling Reactions Catalyzed by Palladium Supported on Silk Fibroin
0316
Hydrogenation of Arenes on a Polymer-Stabilized Palladium–Ruthenium Bimetallic Composite
0317
Quantum Dot-Photocatalyzed Stereoselective Oxidative Dimerization of α-Aryl Ketonitriles
0318
C–C and C–N Cross-Coupling Catalyzed by Polymer-Supported Ni/Pd on Fe3O4@SiO2 Nanoparticles

Organo- and Biocatalysis

z0319
All PDFs of this category
0319
Triplet-Sensitized General Oxyimination of Olefins
0320
Phosphoric Acid Permits Asymmetric Synthesis of Hitherto Underinvestigated Chiral Tetraarylmethanes
0321
Immobilized Chiral Phosphoric Acid Catalysts for Continuous-Flow Desymmetrization of Oxetanes
0322
Enzyme-Controlled Highly Selective N-Alkylation of Pyrazoles with Simple Haloalkanes
0323
Biocatalytic Synthesis of Trisubstituted Cyclopropanes Containing Fluoromethylated Groups
0324
Organophotoredox Catalysis Permits Site-Selective Bioconjugation of Methionine Residues
0325
Visible Light-mediated Enantioselective Radical Addition to α,β-Unsaturated Aldehydes
0326
Chemical Synthesis Reveals the Odorous Principle of Vetiver Oil
0327
Asymmetric Intramolecular Hydroarylations of Nonactivated Olefins with Indoles
0328
Efficient Conversion of CO2 into Cyclic Carbonates with Durable and Recyclable Organoboron Catalysts
0329
Thiophosphorylation of Nucleosides Reveals New Mechanism in Cinchona Alkaloid-Catalysis

Chemistry in Medicine and Biology

z0331
All PDFs of this category
0331
Lysine-Selective Oxidative Addition Complexes for the Conjugation of Proteins, Antibodies, and Peptides
0332
Selective PI3Kγ Inhibitors for in vivo Studies
0333
Inhibition of Mitochondrial Transcription
0334
A Brain-Penetrant mTOR Kinase Inhibitor for the Treatment of Neurological Disorders
0335
Tabernanthalog, an Ibogaine Analogue for Treatment of Addiction and Depression
0336
Covalent Inhibitors and Fluorescent Probes for Investigation of SARS-CoV-2 Mpro in Patient Samples
0337
PET Imaging of Alzheimer’s Disease With a 64Cu Multivalent Bifunctional Chelator
0338
Pamiparib – A Promising PARP Inhibitor
0339
Styrylbenzothiazoles – A New Class of Photoswitches
0340
A Novel and Highly Selective FAK Inhibitor
0341
Antibiotics in a Trojan Horse
0342
Ratiometric Fluorescent Sensing of Intracellular Potassium
0343
The First Synthesis of Morphine

Peptide Chemistry

z0345
All PDFs of this category
0345
Fluorine-Containing Azaheterocyclic β-Amino Acids
0346
Brønsted-Acid-Catalyzed Enantioselective Aza-Friedel–Crafts Reaction
0347
Rhodium-Catalyzed Formation of Disulfide Bonds in Water
0348
Synthesis of Cyclic Peptides by Cooperative Stapling of Native Peptides at Lysine and Tyrosine or Arginine
0349
Synthesis of Tetrasubstituted α-Amino Acids by an Ireland–Claisen Rearrangement
0350
Silver-Promoted Synthesis of Cyclic Peptides by Ring Expansion
0351
Chlorophyll-Catalyzed 1,2-Acyl Migration of Enaminones To Give Quaternary α-Amino Esters
0352
Boron-Containing Aza-Amino Acids
0353
Nickel-Catalyzed Hydroamination of Alkenes
0354
Radical Substitution Reaction for the Synthesis of Nonnatural Amino Acid and Peptides
0355
Late-Stage Site-Selective Rhodium-Catalyzed C(7)-Amidation of Tryptophan Residues
0356
Peptides Synthesis by Using Nitrophenyl Esters

Flow Chemistry

z0357
All PDFs of this category
0357
Synthesis of Hydroxy Esters under Flow Conditions
0358
Rhodium-Catalyzed C–H Activation of Benzylamines for Olefin Hydroarylation
0359
Continuous-Flow Procedure for the Synthesis of Benzotriazoles via [3+2] Cycloaddition
0360
Asymmetric Synthesis of Chloramphenicol and Related Amphenicol Antibiotics

Erratum

0361
Ryabchuk, P; Leischner, T; Kreyenschulte, C; Spannenberg, A; Junge, K; Beller, M: Cobalt-Catalyzed Synthesis of Pyrroles from Nitroarenes