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Synfacts 2021; 17(03): 0356
DOI: 10.1055/s-0040-1706128
Peptide Chemistry

Peptides Synthesis by Using Nitrophenyl Esters

Contributor(s):
Hisashi Yamamoto
,
An Wu
Bodánszky M. * Research Institute of the Pharmaceutical Industry, Budapest, Hungary
Synthesis of Peptides by Aminolysis of Nitrophenyl Esters.

Nature 1955;
175: 685-685
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Key words

dipeptides - nitrophenyl esters - ethyl glycinate

Significance

Peptide-bond formation is extremely important in peptide chemistry. In 1955, Bodánszky used active nitrophenyl esters to form peptide bonds. Before this work, only nonactive esters, such as methyl or ethyl esters, were used in peptide-bond formation.


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Comment

The author gave several examples dipeptide­ synthesis from active amino acid esters. Nitrophenyl­ esters gave much better results than thiophenyl esters.


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Publication History

Article published online:
16 February 2021

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