Bailén MA,
Chinchilla R,
Dodsworth DJ,
Nájera C.
*
Universidad de Alicante, Spain
2-Mercaptopyridone 1-Oxide-Based Uronium Salts: New Peptide Coupling Reagents.
J. Org. Chem. 1999;
64: 8936-8939
Key words
peptide bond formation - uronium salts - coupling agents - thiopyridones
Significance
Peptide coupling reagents are extremely important in peptide synthesis. In 1999, Nájera and co-workers reported a method for synthesizing thiopyridone-derived uronium salts as coupling reagents. The reagents were prepared from cheap starting materials, making them more economical than conventional coupling reagents such as HOBt.
Comment
By using the thiopyridone-derived reagents as coupling reagents, various dipeptides were synthesized in moderate to excellent yields.
