DOI: 10.1055/s-00000131

Synfacts

Issue 05 · Volume 17 · May 2021 DOI: 10.1055/s-011-50777

Synform

A66
Zanda, Matteo: SYNFORM ISSUE 2021/05

Synthesis of Natural Products and Potential Drugs

z0477
All PDFs of this category
0477
Synthesis of (–)-Merrilactone A, (+)-Merrilactone B, and (–)-Anislactones A and B
0478
Synthesis of GDC-0326
0479
Synthesis of Delgocitinib
0480
Total Syntheses of (–)-Daphenylline and (–)-Himalensine A
0481
Synthesis of a Key Subunit of HIV-1 Protease Inhibitor Darunavir
0482
Total Synthesis of (±) Cephanolides A, C, and D
0483
Total Synthesis of (+)-Limaol
0484
Synthesis of Atabecestat
0485
Synthesis of a Key Subunit of HIV-1 Protease Inhibitor Darunavir
0486
Total Synthesis of (+)-Stephadiamine
0487
Synthesis of (+)-2-O-Deacetyl Plebedipenes A and C
0488
Total Synthesis of (±)-Luciduline

Synthesis of Heterocycles

z0489
All PDFs of this category
0489
Synthesis of Indolyl Cyclobutanones by Brønsted Acid Catalysis
0490
Synthesis of 2-Fluoro-1-benzofurans from β,β-Difluoro-o-hydroxystyrenes by 5-endo-trig Cyclization
0491
Explore Three-Dimensional Chemical Space with Triazolobenzodiazepines
0492
Rhodium(III)-Catalyzed Synthesis of Thiobenzofurans
0493
Atroposelective Synthesis of 2-Arylquinazolinones
0494
Nickel-Catalyzed Electrochemical Cross-Coupling of Alcohols and Aryl Halides
0495
Environmentally Friendly Achmatowicz Rearrangement
0496
Synthesis of 2,4,6-Trisubstituted Pyridines from Methyl Ketones and Alkynones
0497
Synthesis of Five-Membered Cyclic Sulfonamide (γ-Sultam) 4,4-Spirocycles
0498
Synthesis of Bi(1,2,3-triazoles) by a Three-Component Reaction
0499
One-Pot Synthesis of 2-Azaaryl Tetrahydroquinolines by a Base-Promoted Reaction
0500
Synthesis of Heterocycles from Potassium Trifluoro(pyrimidin-4-yl)borate Salts

Synthesis of Materials and Unnatural Products

z0501
All PDFs of this category
0501
Orthogonal Functional Group Interconversion
0502
Preparation of Conjugated Azopolymer through Nitrene Dimerization
0503
A New and Efficient Synthetic Route for Preparation of N-Arylphenothiazines
0504
Synthesis of Tetratriazoliumethylene via Cationic Tetranuclear Mesoionic Carbene (MIC)-Ag(I) Complex
0505
Arylene−Imidazolium Based Homopolymers and Copolymers for Anion Exchange Membranes
0506
Expanding the DPP Family
0507
Hydrogen Transfer Crosses the Rubicene
0508
Marriage of Two Structures: Synthesis of an Azadioxa-planar Triphenylborane
0509
Synthesis of Symmetric Conjugated Ladder-Type Polymers with Nitrogen Bridges
0510
Radical Formation of Fused Quinoidal Dithiophene Helicenes
0511
Supersized Indoles by Gold-Catalyzed [8+2]-Cycloadditions
0512
Switchable Synthesis and Applications of 3-Thiosubstituted Pyrroles and Pyrrolines

Metals in Synthesis

z0513
All PDFs of this category
0513
Negishi Cross-Couplings in Water and Deep Eutectic Solvents
0514
Cobalt-Catalyzed Z-Selective Double Bond Transposition
0515
Iridium-Catalyzed Z-Retentive Asymmetric Allylic Substitution Reactions
0516
Nickel-Catalyzed Thioester Synthesis from Thiocarbonates
0517
Palladium-Catalyzed Preparation of Anilines from Cyclohexanones
0518
Dual Rh- and Sm-Catalyzed Enantioselective [4+3] Cycloaddition for the Construction of 1,3-Dioxepines
0519
A Mild and Efficient Protocol for the Oxidation of Hydrazones to Diazo Compounds via Copper Catalysis
0520
Carbonylative C–F Bond Functionalization of gem-Difluoroalkenes with Palladium and Copper Catalysis
0521
Synthesis of β-Hydroxynitriles via Enantioselective Nickel-Catalyzed C–C Bond Formation
0522
Palladium(II)-Catalyzed Enantioselective Desymmetrization Generating Carbazolones
0523
Coupling of Alkynes with Cyclopropyl Ketones in a Samarium-Catalyzed Radical Relay
0524
Ruthenium-Catalyzed Alkylation of Phosphines
0525
Tungsten-Catalyzed SOMOphilic Alkynylations
0526
Copper-Catalyzed Enantioselective α-Arylation of Silylenol Ethers Using Diaryliodonium Salts
0527
Tandem Phosphine- and Pd-Catalyzed Michael–Heck Reaction for the Synthesis of Polyalkyl Furans
0528
Enabling the Use of Alkyl Chlorides in Formal Mizoroki–Heck Couplings via Photoinduced Palladium Catalysis
0529
Nickel-Catalyzed Intermolecular Cross-Electrophile Dialkylation of Alkynes
0530
Gold-Catalyzed Asymmetric Addition of Unactivated Propargylic C–H Bonds to Aldehydes
0531
Palladium/Copper Cooperative Catalysis for C–H Arylation of Five-Membered Heterocycles
0532
C–C Bond Activation in Borylation of Cyclopropanes
0533
Hydroaminoalkylation of Alkenes
0534
Hydrosilane and Cesium Fluoride Triggered Aryne Formation and Subsequent Acylalkylation
0535
ortho-C–H Oxygenation of Weakly Coordinating Amides and Ketones by Rhoda-Electrocatalysis
0536
Hydrogenation via Ascorbic Acid and Cobalt-Photoredox Dual Catalysis
0537
Carbon Nitride–Nickel Heterogeneous Photocatalyst for C–O Bond Formation
0538
Photocatalyzed Deuteration of Carboxylic Acids
0539
Asymmetric Arylation of α-Chlorosulfones
0540
Nickel(0)-Catalyzed Bis-Silylation of Alkynes/Alkenes
0541
The Fukuyama Cross-Coupling Reaction

Polymer-Supported Synthesis

z0543
All PDFs of this category
0543
Benzylic C–H Borylation on Ceria-Supported Nickel Hydroxides
0544
A Magnetic Cu–Phenylurazole Composite for Hydration of Nitriles and Reduction of -NCO, -NCS, and -NC Groups
0545
A Titania-Supported Dual Single-Atom Catalyst for Chemoselective Hydrogenation
0546
N-Arylation of 2-Aminopyridines with Arylboronic Acids Catalyzed by Cu on Phosphorus g-C3N4
0547
Polymer-Supported Brønsted Acid Catalysts for Direct Esterification
0548
Asymmetric Conjugate Addition to Nitrostyrenes Catalyzed by Ni on a Diamine–Sulfonate Copolymer
0549
Synthesis of N-Benzyl Amides by C–H Arylation Catalyzed by Carbon Nitride and Nickel
0550
C–N Coupling Reaction with a Quinoxaline-Based Porous Organic Polymer-Supported Copper Catalyst
0551
Hydrosilylation of Alkenes and Alkynes Catalyzed by Platinum Supported on Carbon Nanotubes
0552
Suzuki–Miyaura Coupling on Palladium–Tellurium Nanoparticles
0553
Meerwein–Ponndorf–Verley Reduction of Aldehydes and Ketones on a Zirconium Organoborate
0554
Photocatalytic Oxidative Amidation of Alcohols on Cu–N–TiO2 under Visible-Light Irradiation
0555
Hydrogenation of Alkenes in Water by Using Pd-PW11/ZrO2
0556
Polymer-Supported Photocatalysts Bearing Phenothiazine and Tris(2,2′-bipyridyl)ruthenium

Organo- and Biocatalysis

z0557
All PDFs of this category
0557
Intermolecular Abiological Hetero-Diels–Alder Reaction Catalyzed by an Artificial Metalloenzyme
0558
Photoexcited Anthraquinone Permits C–H Pyridylation of Simple Nonactivated Hydrocarbons
0559
Chiral Phosphoric Acid Catalysts Can Control the Stereoselectivity of Nucleoside Phosphitylations
0560
Catalytic Asymmetric Fischer Indolization by Desymmetrization of Cyclopentane-1,3-diones
0561
Enzymatic Zinc Hydrides Expand New-to-Nature Toolbox
0562
Novel P-Stereogenic Organocatalysts Permit Desymmetrizing Enantioselective Reduction
0563
Imine Reductase-Catalyzed Reductive Amination of α-Keto Esters Yields N-Substituted α-Amino Esters
0564
Making Primary Amine Synthesis Simple: Photocatalytic Olefin Hydroamination
0565
Catalytic Asymmetric Aminomethylation of Bis-Silyl Ketene Acetals to β2-Amino Acids
0566
Organocatalytic Selective Depolymerization of Mixed Plastics

Chemistry in Medicine and Biology

z0567
All PDFs of this category
0567
Targeted Tumor Therapy via Extracellular Calcification
0568
EC5026, an Analgesic Without the Addictive Potential of Opioids
0569
Synthesis of cis-Aminopiperidine by Asymmetric Hydrogenation
0570
BET Bromodomain Inhibitors Promote Wound Healing
0571
Toward Catalytic Antibiotics
0572
A New Approach for the Synthesis of Covalent Inhibitor Libraries
0573
Discovery of LYS006, an Inhibitor of Leukotriene A4 Hydrolase for the Treatment of Inflammatory Diseases
0574
Targeting Mutant BRAF with PROTACs
0575
Enantioselective Diacetoxylation of Terminal Alkenes
0576
E7766, a Novel Interferon Genes (STING) Agonist
0577
The First Total Synthesis of Cocaine
0578
Synthesis of (±)-Uvaridacol L: An Antiausterity Agent

Peptide Chemistry

z0579
All PDFs of this category
0579
Catalytic Intramolecular C–H Alkylation for the Synthesis of Peptide Macrocycles
0580
Phase-Transfer-Catalyzed Synthesis of 4-Cyanotryptophan
0581
Palladium-Catalyzed Intramolecular Peptide Macrocyclization
0582
Synthesis of α-Sulfanyl-β-Amino Acids by a Mannich-Type Reaction
0583
[3+2] Photocycloaddition of a Cyclopropylurea with α-Substituted Acrylates
0584
Visible-Light Photoredox-Catalyzed Redox-Neutral Carbocarboxylation of Activated Alkenes
0585
Organophotoredox and Hydrogen Atom Transfer Catalysis for the Synthesis of β-Silyl α-Amino Acids
0586
Palladium/Copper Catalysis to Access α-Amino Esters
0587
Thiopyridone-Derived Reagents for Peptide Coupling Reactions

Flow Chemistry

z0589
All PDFs of this category
0589
Catalytic Si–H Functionalization in Flow
0590
UV-Mediated Synthesis of 1,3,4-Oxadiazoles in Flow
0591
Improved Flow Synthesis of Remdesivir
0592
Zirconium Oxide Catalyzed Amidation Reactions Using Unactivated Esters in Flow
0593
Generation and Use of Pyrylium Tetrafluoroborates in Polymerization under Continuous-Flow Conditions
0594
Synthesis of Primary Amides by Site-Selective Hydrolysis
0595
Photocatalytic Hydrocarboxylation in Flow for β-Lactone Synthesis