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Synfacts 2021; 17(05): 0587
DOI: 10.1055/s-0040-1706184
Peptide Chemistry

Thiopyridone-Derived Reagents for Peptide Coupling Reactions

Rezensent(en):
Hisashi Yamamoto
,
An Wu
Bailén MA, Chinchilla R, Dodsworth DJ, Nájera C. * Universidad de Alicante, Spain
2-Mercaptopyridone 1-Oxide-Based Uronium Salts: New Peptide Coupling Reagents.

J. Org. Chem. 1999;
64: 8936-8939
CrossrefPubMedSuche in Google Scholar
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Key words

peptide bond formation - uronium salts - coupling agents - thiopyridones

Significance

Peptide coupling reagents are extremely important in peptide synthesis. In 1999, Nájera and co-workers reported a method for synthesizing thiopyridone-derived uronium salts as coupling reagents. The reagents were prepared from cheap starting materials, making them more economical than conventional coupling reagents such as HOBt.


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Comment

By using the thiopyridone-derived reagents as coupling reagents, various dipeptides were synthesized in moderate to excellent yields.


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Publikationsverlauf

Artikel online veröffentlicht:
20. April 2021

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