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Synfacts 2021; 17(08): 0941
DOI: 10.1055/s-0040-1706271
DOI: 10.1055/s-0040-1706271
Peptide Chemistry
Synthesis of Azobenzene-Functionalized Peptides by Modification of Tyrosine-Containing Peptides
Wang P,
Cheng Y,
Wu C,
Zhou Y,
Cheng Z,
Li H,
Wang R,
*,
Su W,
*,
Fang L.
*
Lanzhou University and Shenzhen Institute of Advanced Technology, Shenzhen, P. R.
of China
Tyrosine-Specific Modification via a Dearomatization–Rearomatization Strategy: Access to Azobenzene Functionalized Peptides.
Org. Lett. 2021;
23: 4137-4141
DOI: 10.1021/acs.orglett.1c01013
Tyrosine-Specific Modification via a Dearomatization–Rearomatization Strategy: Access to Azobenzene Functionalized Peptides.
Org. Lett. 2021;
23: 4137-4141
DOI: 10.1021/acs.orglett.1c01013
Significance
Azobenzene-functionalized peptides are important because of their distribution in photoresponsive biosystems. The authors report a new strategy for preparing azobenzene-functionalized peptides from tyrosine-containing peptides and phenylhydrazine.
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Comment
By using (diacetoxyiodo)benzene, various peptides containing an azobenzene motif were synthesized with good chemoselectivity and site selectivity in moderate yields.
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Publikationsverlauf
Artikel online veröffentlicht:
20. Juli 2021
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