Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2021; 17(08): 0941
DOI: 10.1055/s-0040-1706271
DOI: 10.1055/s-0040-1706271
Peptide Chemistry
Synthesis of Azobenzene-Functionalized Peptides by Modification of Tyrosine-Containing Peptides
Wang P,
Cheng Y,
Wu C,
Zhou Y,
Cheng Z,
Li H,
Wang R,
*,
Su W,
*,
Fang L.
*
Lanzhou University and Shenzhen Institute of Advanced Technology, Shenzhen, P. R. of China
Tyrosine-Specific Modification via a Dearomatization–Rearomatization Strategy: Access to Azobenzene Functionalized Peptides.
Org. Lett. 2021;
23: 4137-4141
DOI: 10.1021/acs.orglett.1c01013.
Tyrosine-Specific Modification via a Dearomatization–Rearomatization Strategy: Access to Azobenzene Functionalized Peptides.
Org. Lett. 2021;
23: 4137-4141
DOI: 10.1021/acs.orglett.1c01013.
Significance
Azobenzene-functionalized peptides are important because of their distribution in photoresponsive biosystems. The authors report a new strategy for preparing azobenzene-functionalized peptides from tyrosine-containing peptides and phenylhydrazine.
#
Comment
By using (diacetoxyiodo)benzene, various peptides containing an azobenzene motif were synthesized with good chemoselectivity and site selectivity in moderate yields.
#
#
Publication History
Article published online:
20 July 2021
© 2021. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany