Genov GR,
Douthwaite JL,
Lahdenperä AS. K,
Gibson DC,
Phipps RJ.
* University of Cambridge, UK
Enantioselective Remote C–H Activation Directed by a Chiral Cation.
Science 2020;
367: 1246-1251
Key words
iridium catalysis - C–H activation - enantioselectivity - regioselectivity - chiral cations
Significance
Phipps and co-workers report the application of chiral cation–anion ligand pairing in iridium complexes to achieve long-range asymmetric induction for C–H borylation. The reaction proceeds with low catalyst loading, affording the product in good yield with high regio- and enantioselectivity.
Comment
The authors propose that the control of enantioselectivity is enabled by the chiral cation employed in the iridium complex. Notably, both phosphorous and carbon stereocenters can be formed, depending on the substrate class employed.
