DOI: 10.1055/s-00000131

Synfacts

Issue 08 · Volume 16 · August 2020 DOI: 10.1055/s-010-49005

Synform

A108
Zanda, Matteo: SYNFORM ISSUE 2020/08

Synthesis of Natural Products and Potential Drugs

z0875
All PDFs of this category
0875
Total Synthesis of (+)-1,2-Dehydroaspidospermidine, (+)-Condyfoline, and (–)-Tubifoline
0876
Total Synthesis of (±)-11-O-Debenzoyltashironin
0877
Synthesis of Sacubitril
0878
Synthesis of an Allosteric Inhibitor of the Mutant GTPase KRASG12C
0879
Total Syntheses of (+)-Cheloviolene C, (+)‑Seconorrisolide B, and (+)-Seconorrisolide C
0880
Synthesis of a Bcl-2 Antagonist
0881
Synthesis of Mevidalen
0882
Synthesis of (–)-Glaucocalyxin A
0883
Synthesis of (+)-Bryostatin 3
0884
Synthesis of (+)-Oxo-tomaymycin
0885
Synthesis of Monobactam Antibiotic LYS228
0886
Synthesis of an HIV-1 Protease Inhibitor
0887
Total Synthesis of (–)-Taxol
0888
Synthesis of Remibrutinib
0889
Synthesis of UCB-108770 via a Povarov Cycloaddition
0890
Synthesis of Zoliflodacin
0891
Total Synthesis of (±)-Indolizomycin
0892
Synthesis of ABBV-744

Synthesis of Heterocycles

z0893
All PDFs of this category
0893
Selective C2-H Amination
0894
NHC-Catalyzed Chemo- and Enantioselective Synthesis of 3,4‑2H‑Pyridin-2-ones
0895
Potassium Carbonate-Catalyzed Synthesis of Highly Functionalized Indoles
0896
Rhodium-Catalyzed Synthesis of Enantioenriched Phthalides
0897
Copper-Catalyzed Synthesis of Highly Functionalized Pyrroles from Allenoates
0898
A Mild Skraup Quinoline Synthesis from Anilines and Epoxides
0899
Synthesis of Benzodiazepines from Benzimidazolium Salts
0900
Combined Chemoenzymatic Sequence for the Synthesis of γ-Lactones
0901
Efficient Electrochemical Synthesis of 2-Aryl-1,2,3-Benzotriazoles and their N-Oxides
0902
Benzyne-Mediated Ring Opening of DABCO: Synthesis of 1,4-Disubstituted Piperazines and Piperidines
0903
Synthesis of Tricyclic Indoles from Iodoalkynes and an N-Tosyl Hydroxylamine
0904
Silver(I)-Catalyzed 1,3-Dipolar Cycloaddition Route to Fully Substituted Pyrrolidines
0905
Intramolecular N-Halovinylation to Synthesize Cyclic β-Haloenamides
0906
Asymmetric Synthesis of α-Carboline Derivatives

Synthesis of Materials and Unnatural Products

z0907
All PDFs of this category
0907
E-Beam COFs
0908
When Helicates Stick Together
0909
Reaction of Anthracene and Quinone to Aryl Ethers
0910
Old Polymerization, New Insights
0911
Rare Oxepino-Pyridines via Domino Double Annulation
0912
Fuse Aromatics with O-Containing Rings
0913
Choose Your Own Adventure: Furan Edition
0914
From Carbon Nanobelts to Cycloiptycenes
0915
A Fluorene-Based Oxygen-Containing Carbon Diradical
0916
Two Condensation Reactions Construct Tetrazaacenes
0917
Point to Mechanically Chiral Planes
0918
A TACtful Approach to Stable Organic Radical Synthesis

Metals in Synthesis

z0919
All PDFs of this category
0919
Chiral Cation–Anion Ligand Pair Directs Highly Selective Remote C–H Activation
0920
A Solvent Switch Enabling Variation of the Regioselectivity of Indoline Alkylation
0921
Nickel/Benzophenone Dual-Catalyzed Synthesis of Unsymmetrical Ketones
0922
Coupling of Allylic Alcohols Using Nickel Catalysis
0923
Iridium-Catalyzed Stereoselective Alkene Isomerization
0924
Nickel-Catalyzed Preparation of Skipped Dienes and Trienes
0925
Nickel-Catalyzed Site-Selective Asymmetric Hydroarylation of 1,3-Dienes
0926
Asymmetric Synthesis of Heterocycles by Palladium-Catalyzed Tandem Allylic Substitution
0927
Enantioconvergent Amination of Racemic Tertiary C(sp3)–H Bonds
0928
Enantioselective Biaryl Synthesis Enabled by Electrochemical Nickel Catalysis
0929
Electrochemical Enantioselective C(sp3)–H Alkynylation of Tertiary Cyclic Amines
0930
Nickel-Catalyzed α-Carbonylalkylarylation of Vinylarenes
0931
Palladium-Catalyzed Photoinduced Carbofunctionalization of Conjugated Dienes
0932
Multicomponent, Interrupted Radical Heck Coupling
0933
Enantioselective Sonogashira-Type Coupling
0934
Preparation of Pyrroles via a CuH-Catalyzed Coupling of Nitriles and Enynes
0935
CuH-Catalyzed Enantioselective Synthesis of Indazoles Bearing a Chiral C3-Quaternary Center
0936
Synthesis of β-Stereogenic Arenes by Pd/Cu Dual Catalysis
0937
Cross-Electrophile Coupling between Alkyl and Aryl Chlorides
0938
Synthesis of Chiral Fluorenes by Rhodium-Catalyzed Asymmetric Carbene C(sp2)–H Insertion
0939
Synthesis of Chiral α-Fluorinated Diarylmethanes by Asymmetric Cobalt-Catalyzed Cross-Coupling
0940
Transformations of Aryl Ketones via Ligand-Promoted C–C Bond Activation
0941
Palladium-Catalyzed γ‑C(sp3)–H Fluorination of Primary Amines
0942
A Highly Stereoselective Hydrogenation of α-Substituted β-Ketoamides
0943
Late-Stage Functionalization C–H Methylation Enabled by Cobalt Catalysis
0944
Preparation of the 1,3-Dienyl-6-oxy Polyketide Motif
0945
Light-Promoted Nickel-Catalyzed C–O Cross-Coupling
0946
The Grignard Reaction

Polymer-Supported Synthesis

z0947
All PDFs of this category
0947
α,β-Desaturation of Ketones Catalyzed by Palladium(II) on Gold Nanoparticles Supported on Ceria
0948
Suzuki–Miyaura Coupling on a Triazolyl-Functionalized Hypercrosslinked Polymer–Palladium Catalyst
0949
Synthesis of 1,3,4-Trisubstituted and 1,4-Disubstituted Pyrazoles on Montmorillonite K10
0950
Transfer Hydrogenation of Furfurals Catalyzed by Methanol-Activated Zirconium/MOF-808
0951
Oxidation of Sulfides and Alkenes on an Immobilized Manganese(III)–Schiff Base Complex
0952
A New CN Source for the Palladium-Catalyzed Cyanation of Aryl Halides
0953
Hydrogenation of Arylamines Catalyzed by Ruthenium Nanoparticles on Graphitic Carbon Nitride
0954
Synthesis of Chalcone and Dihydrochalcone Derivatives from Methyl Ketones and Primary Alcohols
0955
Synthesis of Esters and Lactones by Carboxylation of Terminal Alkynes on Ag Nanoparticle-Doped MgO
0956
Borylation of Alkyl Halides Catalyzed by Copper Nanoparticles on Dopamine-Functionalized Nano-Fe3O4
0957
Silver Photocatalytic Synthesis of 2-Arylquinolines from N-Benzylanilines and Alcohols

Organo- and Biocatalysis

z0959
All PDFs of this category
0959
Enzyme-Catalyzed Asymmetric Primary Amination of Benzylic and Allylic C(sp3)–H Bonds
0960
Asymmetric Ring-Opening Desymmetrization of Substituted Oxetanes
0961
Pyridoxal- and Ketoreductase-Catalyzed DKR Permits Stereodivergent Synthesis of 1,2-Amino Alcohols
0962
Proton-Coupled-Electron-Transfer-Mediated Enantioselective Hydroamination of Alkenes
0963
Synthesis of Difluoromethylated Tetrasubstituted Stereocenters by Chiral Anion Phase-Transfer Catalysis
0964
Isothiourea-Catalyzed Kinetic Resolution of Tertiary α-Hydroxy Esters
0965
Thiourea Catalyst Governs Novel Enantioselective S–H Insertion of α-Carbonyl Sulfoxonium Ylides to Arylthiols
0966
A Dianionic Phase-Transfer Catalyst Directs the Dearomatization of 2-Naphthols
0967
Asymmetric Decarboxylative Mannich-Type Additions by Synergistic Phosphine–Allenoate Organocatalysis
0968
Phosphine-Catalyzed Phosphinoboration of Propiolates
0969
Catalytic Photochemical Deracemization of Allenes

Chemistry in Medicine and Biology

z0971
All PDFs of this category
0971
Covalent Inhibition of Ras G12C with a Stapled Peptidomimetic
0972
Discovery and Characterization of a Diels–Alderase
0973
Discovery of a CNS-Active Inhibitor of NAPE-PLD
0974
Inhibition of the Pentose Phosphate Pathway Reveals its Importance in the Immune Response
0975
Synthetic Cystobactamid Antibiotics With Improved Activities
0976
Visible-Light-Induced Arene Dearomatization Cascades
0977
Two-Stage Photocatalytic Diamination of Alkenes
0978
Taking Two Monopolar Spindle 1 Kinase Inhibitors to Clinical Trials
0979
Synthesis of Azidoribose Probes to Track Ketoamine Adducts
0980
Fluorophores, Get On My Nerves!
0981
Controlling the Actin Cytoskeleton with Light
0982
Discovery and Total Synthesis of Anaenamides A and B
0983
Optical Control of CRAC Channels
0984
Lipid Tails Make the Difference!
0985
Photoinduced Electron Transfer for the Selective Labeling of Tryptophan Residues
0986
Chrysomycin A and Derivatives against Multi-Drug-Resistant Tuberculosis
0987
Protein−Protein Cross-Coupling with an Electrophilic Palladium Reagent
0988
The First SHP2 PROTAC
0989
Synthesis of the First FDA-Approved HIV Protease Inhibitor

Peptide Chemistry

z0991
All PDFs of this category
0991
Copper-Catalyzed Synthesis of Nonnatural α-Amino Acids
0992
Synthesis of Fluorodehydroalanine-Containing Peptides
0993
Rhodium-Catalyzed Synthesis of α-Amino Acid Derivatives
0994
Nickel-Catalyzed Hydrogenation to Form α-Amino Acid Derivatives
0995
Palladium-Catalyzed Synthesis of α-Amino Acid Derivatives from Hydrazones and Boronic Acids
0996
Deracemization Strategy for the Synthesis of Nonnatural Amino Acid Derivatives
0997
Catalytic Two-Step Synthesis of Azetidine 3-Aryl-3-Carboxylic Acids
0998
Iron-Catalyzed Synthesis of α,α-Disubstituted Amino Acids from Azlactones and Indoles
0999
Synthesis of Allylic Amino Acid Derivatives by a Palladium-Catalyzed Cross-Coupling Reaction
1000
Synthesis of β2-Amino Acids from β-Phthalimido-α-xanthylpropionic Acids by Radical Addition

Flow Chemistry

z1001
All PDFs of this category
1001
Synthesis of Deuterodifluoromethylated Alcohols and gem-Difluoroalkenes in Continuous Flow
1002
Synthesis of Oxindoles by a Photo-Fenton Reaction
1003
Polystyrene-Supported Carbodiimide: A Flow Protocol for Amide/Lactam Synthesis
1004
Synthesis of Isocyanates from Carboxylic Acids in Continuous Flow
1005
Selective Hydroboration/Oxidation of Alkenes Using 9-BBN under Flow Conditions
1006
Stereospecific Amination Using Sodium Azide in Continuous Flow
1007
Kinetic Resolution of BINOLs in Continuous Flow