Iron-Catalyzed Aerobic Oxidative Cross-Dehydrogenative C(sp³)–H/X–H (X = C, N, S) Coupling Reactions

Abstract

The direct functionalization of C(sp³)–H bonds is an attractive research topic in organic synthetic chemistry. The cross-dehydrogenative coupling (CDC) reaction provides a simple and powerful tool for the construction of C–C and C–heteroatom bonds. Recently, some progress has been made in the iron-catalyzed aerobic oxidative CDC reactions. Here, we present recent developments in the direct functionalization of C(sp³)–H bonds catalyzed by simple iron salts with molecular oxygen as the terminal oxidant.

1 Introduction

2 C(sp³)–C Bond Formation

3 C(sp³)–N Bond Formation

4 C(sp³)–S(Se) Bond Formation

5 Conclusion and Outlook

Key words

iron - cross-coupling reaction - aerobic oxidative reaction - green synthesis - synthetic methods

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