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Synfacts 2020; 16(05): 0563
DOI: 10.1055/s-0040-1707550
DOI: 10.1055/s-0040-1707550
Metals in Synthesis
Grubbs Catalyst 2nd Generation: Synthesis and Activity of Ruthenium-Based Olefin Metathesis Catalysts
Further Information
Publication History
Publication Date:
20 April 2020 (online)
![](https://www.thieme-connect.de/media/synfacts/202005/i_l044_s1_10-1055_s-0040-1707550.gif)
Significance
Grubbs and co-workers reported a direct approach towards the preparation of the 4,5-dihydroimidazol-2-ylidene-substituted ruthenium-based catalysts. Compared to their predecessor, these 2nd generation catalysts display higher reactivity, better stability, and improved functional group tolerance.
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Comment
Conveniently, these 2nd generation catalysts are air- and water-tolerant and can be handled without great loss in activity. Given the increased RCM activities observed with (A) and (B), the authors studied RCM at lower catalyst loadings and found 0.05 mol% to be an optimal lower limit in both cases.
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Review
O. M. Ogba, N. C. Warner, D. J. O’Leary, R. H. Grubbs Chem. Soc. Rev. 2018, 47, 4510–4544.
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![](https://www.thieme-connect.de/media/synfacts/202005/i_l044_s1_10-1055_s-0040-1707550.gif)