Group-Selective Approaches to Complex Natural Product Synthesis: Three Examples of Diastereotopos-Selective Reactions

Dedicated to Profs. Masaji Ohno, Susumu Kobayashi and Reinhard W. Hoffmann

Abstract

This Account showcases three diastereotopos-selective reactions exploited in our complex natural syntheses.

1 Introduction

2 Malyngolide: Hydroalumination of Bisalkynyl tert-Alcohols

3 Cavicularin: Acetal Cleavage

4 Carthamin: Bromoacetoxylation

5 Conclusions

Key words

asymmetrization - differentiation - group selectivity - natural product synthesis - topos selectivity

Publication History

Received: 30 August 2021

Accepted after revision: 08 September 2021

Article published online:
13 October 2021

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