Synthesis of a Side-Chain-Tethered Solid Support for Peptide Synthesis

Key words

solid-phase peptide synthesis - silicon-linked solid support - β-amino acids

Significance

Silicon-linked solid supports play a major role in peptide syntheses because of the ease with which silicon-based linkers can be attached and detached. In 2000, Lee and Silverman developed silicon-linked side-chain-tethered β-amino acid building blocks for peptide synthesis.

Comment

The silicon-linked side-chain-tethered β-amino acid building blocks were synthesized in good yields. The synthesized support permits the elongation of a peptide chain at both its C-terminal and N-terminal directions. Furthermore, it can be used for the synthesis of 3-aryl-β-alanine-containing tripeptides in good yields.

Publication History

Article published online:
17 September 2021