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Synfacts 2021; 17(10): 1161
DOI: 10.1055/s-0040-1719978
Peptide Chemistry

Synthesis of Sulfonyl Fluoro Peptides by an Ugi Reaction

Contributor(s):
Hisashi Yamamoto
,
Tomohiro Hattori
Xu S, Cui S. * Zhejiang University, Hangzhou, P. R. of China
SuFExable Isocyanides for Ugi Reaction: Synthesis of Sulfonyl Fluoro Peptides.

Org. Lett. 2021;
23: 5197-5202
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Key words

sulfonyl fluoro peptides - sulfonyl isocyanides - click chemistry - Ugi reaction

Significance

Sulfonyl fluoro amino acids could play significant roles in peptide modifications or the synthesis of bioactive peptides. The authors have developed a synthesis of sulfonyl fluoro peptides from sulfonyl isocyanide by using an Ugi reaction.


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Comment

Various sulfonyl fluoro peptides were formed by the Ugi reaction. The resulting peptides could be used in click chemistry.


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Publication History

Article published online:
17 September 2021

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